Research in the Tolar Lab focuses on finding new ways of treating children with lethal diseases - cancer, inborn errors of metabolism, and devastating genetic disorders - using stem cell transplantation.
Our work also involves looking for safer and more effective methods of repairing and using a patient's own cells in diseases such as epidermolysis bullosa, mucopolysaccharidosis type I (Hurler syndrome), Fanconi anemia, and dyskeratosis congenita.
Additional research interests include:
- reducing the negative effects of stem cell transplantation (such as using mesenchymal stromal cells for graft-versus-host disease),
- creation and use of induced pluripotent stem cells,
- gene therapy using gene addition (with viral vectors and trasposons),
- or gene editing (with synthetic nucleases to repair genes).
Our Lab Locations
The Tolar Lab has two locations on the University of Minnesota campus, allowing unique collaborations between a variety of disciplines. The Stem Cell Team is located in the Stem Cell Institute in McGuire Translational Research Facility (MTRF) while the Cancer Team has space in the Masonic Cancer Research Building (MCRB).
Research ethics at the University of Minnesota
We are committed to protecting research participants, upholding ethical standards, and improving our practice at every step of our work.
Learn more about our commitment to research ethics