Tolar Laboratory

Tolar Lab

The Tolar Team is driven to find better and safer therapies for children with serious medical conditions.

Research Interests

The Tolar Team studies the cellular and molecular processes of genetic disorders and how to treat them. In particular, they focus on those without a cure. For the painful skin disease epidermolysis bullosa—which they were the first in the world to treat with bone marrow transplant--researchers investigate aspects such as the autoimmune component of the disease, gene therapy, wound healing, and skin replacement. Bone marrow failure disorders, such as Fanconi anemia, dyskeratosis congenita, and lysosomal and peroxisomal disorders, such as mucopolysaccharidoses and adrenoleukodystrophy—all currently treated with bone marrow transplant—are also being researched as potential targets for gene therapy. The laboratory team works together to combine a wide array of strengths and expertise, and is an active and enthusiastic collaborator with many other projects.

Contact

Contact

Lab Address
Masonic Cancer Research Building
425 East River Parkway
Labs on 4th, 6th, and 7th floors
Minneapolis, MN. 55455

Stem Cell Institute Labs
McGuire Translational Research Facility
Labs on 2nd and 4th floors

Cancer Team
Team Lead
Cindy Eide
eidex007@umn.edu
Phone: 612-625-2966

Stem Cell Institute Team
Team Lead
Kirk Twaroski
ktwarosk@umn.edu
Phone: 612-626-6723


Mailing Address
Masonic Cancer Research Building
Room 460A
425 East River Parkway
Minneapolis, MN 55455

Locations

Locations

The Tolar Lab has two locations on the University of Minnesota campus, allowing unique collaborations between a variety of disciplines. The Stem Cell Team is located in the Stem Cell Institute in McGuire Translational Research Facility (MTRF) while the Cancer Team has space in the Masonic Cancer Research Building (MCRB).

Publications

Publications

  1. Jakub Tolar Publications [H-Index = 42] Peer-Reviewed Publications – Medical Jakub Tolar Publications [H-Index = 42] Peer-Reviewed Publications – Medical 
  2. Onoufriadis A, Hsu C-K, Eide CR, Nanda A, Orchard GE, Tomita K, Sheriff A, Scott W, Tierney C, Lee JYW, Gomaa NS, Desomchoke R, Lwin SM, Tu W-T, Chen L-Y, Huang H-Y, Chao S-C, Lee JY-Y, Bare Y, Hayday T, Guy AL, Liu L, Lees C, Hirdler T, Lovell P, Xia L, Dayrit JF, Calonje E, Simpson MA, Tolar J, Parsons M, McGrath J. Semi-dominant GPNMB mutations in amyloidosis cutis dyschromica. Accepted by J Invest Dermatol. 2019 May 10.
  3. Eisengart JB, Pierpont EI, Kaizer AM, Rudser KD, King KE, Pasquali M, Polgreen LE, Dickson PI, Le SQ, Miller WP, Tolar J, Orchard PJ, Lund TC. Intrathecal enzyme replacement for Hurler syndrome: biomarker association with neurocognitive outcomes. Genet Med. 2019 Apr 25. http://dx.doi.org/10.1038/s41436-019-0522-1. PMID: 31019279. [Epub ahead of print]
  4. Twaroski K, Eide C, Riddle MJ, Xia L, Lees CJ, Chen W, Mathews W, Keene DR, McGrath JA, Tolar J. Revertant mosaic fibroblasts in recessive dystrophic epidermolysis bullosa. Br J Dermatol. 2019 Mar 29. http://dx.doi.org/10.1111/bjd.17943. PMID: 30924923. [Epub ahead of print]
  5. Ebens CL, McGrath JA, Tamai K, Hovnanian A, Wagner JE, Riddle MJ, Keene DR, DeFor TE, Tryon R, Chen M, Woodley DT, Hook K, Tolar J. Bone marrow transplant with post-transplant cyclophosphamide for recessive dystrophic epidermolysis bullosa expands the related donor pool and permits tolerance of non-hematopoietic cellular grafts. Br J Dermatol. 2019 Mar 5; http://dx.doi.org/10.1111/bjd.17858. PMID: 30843184. [Epub ahead of print]
  6. Boyle WS, Chen W, Rodriguez A, Linn S, Tolar J, Lozano K, Reineke TM. Ternary composite nanofibers containing chondroitin sulfate scavenge inflammatory chemokines from solution and prohibit squamous cell carcinoma migration. ACS Appl Bio Mater. 2019 Feb 20;30(2):418-431. http://dx.doi.org/10.1021/acsabm.8b00690. PMID: 30525482.
  7. Boyle WS, Twaroski K, Woska EC, Tolar J, Reineke TM. Molecular additives significantly enhance glycopolymer-mediated transfection of large plasmids and functional CRISPR-Cas9 transcription activation ex vivo in primary human fibroblasts and induced pluripotent stem cells. Bioconjug Chem. 2019 Feb 20;30(2):418-431. http://dx.doi.org/10.1021/acs.bioconjchem.8b00760. PMID: 30525482. 
  8. Xing Y, Smith MJ, Goetz CA, McElmurry RT, Parker SL, Min D, Hollander GA, Weinberg KI, Tolar J, Stefanski HE, Blazar BR. Thymic epithelial cell support of thymopoiesis does not require Klotho. J Immunol. 2018 Dec 1;201(11):3320-3328. http://dx.doi.org/10.4049/jimmunol.1800670. PMID: 30373854. PMCID: PMC6275142.
  9. Jung JP, Lin WH, Riddle MJ, Tolar J, Ogle B. A 3D in vitro model of the dermoepidermal junction amenable to mechanical testing. J Biomed Mater Res Part A. 2018 Dec;106(12):3231-3238. http://dx.doi.org/10.1002/jbm.a.36519. PMID: 30208260. PMCID: PMC6283247.
  10. Banga A, Dutton J, Mysz M, Norris B, Flory C, Ogle B, Tolar J, Schumacher R. Engraftment of reprogrammed human bile duct cells transiently rescues diabetes in mice. J Stem Cell Res Ther. 2018; 8:433. http://dx.doi.org/10.4172/2157-7633.1000432. 
  11. Fioredda F, Iacobelli S, Korthof ET, Knol C, van Biezen A, Bresters D, Veys P, Yoshimi A, Fagioli F, Mats B, Zecca M, Faraci M, Miano M, Arcuri L, Maschan M, O'Brien T, Diaz MA, Sevilla J, Smith O, Peffault de Latour R, de la Fuente J, Or R, Van Lint MT, Tolar J, Aljurf M, Fisher A, Skorobogatova EV, Diaz de Heredia C, Risitano A, Dalle JH, Sedláček P, Ghavamzadeh A, Dufour C. Outcome of haematopoietic stem cell transplantation in dyskeratosis congenita. Br J Haematol. 2018 Jul 9;183:110-8. http://dx.doi.org/10.1111/bjh.15495. PMID: 29984823.
  12. Pennell CA, Barnum JL, McDonald-Hyman CS, Panoskaltsis-Mortari A, Riddle MJ, Xiong Z, Loschi M, Thangavelu G, Campbell HM, Storlie MD, Refaeli Y, Furlan SN, Jensen MC, Kean LS, Miller JS, Tolar J, Osborn MJ, Blazar BR. Human CD19-targeted mouse T cells induce B Cell aplasia and toxicity in human CD19 transgenic mice. Mol Ther. 2018 Jun 6;26(6):1423-1434. http://dx.doi.org/10.1016/j.ymthe.2018.04.006. PMID: 29735365. PMCID: PMC5986973.
  13. Zhu Z, Guo SZ, Hirdler T, Eide C, Fan X, Tolar J, McAlpine MC. 3D printed functional and biological materials on moving freeform surfaces. Adv Mater. 2018 Jun;30(23):e1707495. http://dx.doi.org/10.1002/adma.201707495. PMID: 29691902. PMCID: PMC6310159.
  14. Zhang H, Lee CAA, Li Z, Garbe JR, Eide CR, Petegrosso R, Kuang R, Tolar J. A multitask clustering approach for single-cell RNA-seq analysis in recessive dystrophic epidermolysis bullosa. PLOS Comput Biol. 2018 Apr 9;14(4):e1006053. http://dx.doi.org/10.1371/journal.pcbi.1006053. eCollection 2018 Apr. PMID: 29630593. PMCID: PMC5908193.
  15. Osborn MJ, Lees CJ, McElroy AN, Merkel SC, Eide CR, Mathews W, Feser CJ, Tschann M, McElmury RT, Webber BR, Kim CJ, Blazar BR, Tolar J. CRISPR/Cas9-based cellular engineering for targeted gene overexpression. Int J Mol Sci. 2018 Mar 22;19(4). pii: E946. http://doi.org/10.3390/ijms19040946. PMID: 29565806. PMCID: PMC5979553.
  16. Lee CAA, Seo HS, Armien AG, Bates FS, Tolar J, Azarin SM. Modeling and rescue of defective blood-brain barrier function of induced brain microvascular endothelial cells from childhood cerebral adrenoleukodystrophy patients. Featured article, Fluids Barriers CNS. 2018 Apr 4;15(1):9. http://doi.org/10.1186/s12987-018-0094-5. PMID: 29615068. PMCID: PMC5883398.
  17. Tolar J, Bauer JW, Kaplan DH, Leachman SA, McGrath JA, Paller AS, Griffith-Bauer KA, Stemwedel CE, Kulesz-Martin MF. Montagna Symposium 2017-Precision Dermatology: Next Generation Prevention, Diagnosis, and Treatment. J Invest Dermatol. 2018 Jun;138(6):1243-1248. http://dx.doi.org/10.1016/j.jid.2018.02.039. PMID: 29550416. PMCID: PMC5970097.
  18. Rousseaux MWC, Tschumperlin T, Lu HC, Lackey EP, Bondar VV, Wan YW, Tan Q, Adamski CJ, Friedrich J, Twaroski K, Chen W, Tolar J, Henzler C, Sharma A, Bajić A, Lin T, Duvick L, Liu Z, Sillitoe RV, Zoghbi HY, Orr HT. ATXN1-CIC complex Is the primary driver of cerebellar pathology in spinocerebellar ataxia type 1 through a gain-of-function mechanism. Neuron. 2018 Mar 21;97(6):1235-1243. http://dx.doi.org/10.1016/j.Neuron.2018.02.013. PMID: 29526553.]
  19. Felices M, Lenvik AJ, McElmurry R, Chu S, Hinderlie P, Bendzick L, Geller MA, Tolar J, Blazar BR, Miller JS. Continuous treatment with IL-15 exhausts human NK cells via a metabolic defect. JCI Insight. 2018;3(3):e96219. https://dx.doi.org/10.1172/jci.insight.96219. PMID: 29415897. PMCID: PMC5821201.
  20. Du J, Flynn R, Paz K, Ren HG, Ogata Y, Zhang Q, Gafken PR, Storer BE, Roy NH, Burkhardt JK, Mathews W, Tolar J, Lee SJ, Blazar BR, Paczesny S. Murine chronic graft-versus-host disease proteome profiling discovers CCL15 as a novel biomarker in patients. Blood. 2018 Apr 12;131(15):1743-1754. http://dx.doi.org/10.1182/blood-2017-08-800623. PMID: 29348127. PMC5897867.
  21. Bruckner AL, Fairclough DL, Feinstein JA, Lara-Corrales I, Lucky AW, Tolar J, Pope E. Reliability and validity of iscorEB (Instrument for Scoring Clinical Outcomes of Research for Epidermolysis Bullosa). Br J Dermatol. 2018 May;178(5):1128-1134. http://dx.doi.org/10.1111/bjd.16350. PMID: 29341069. 
  22. Matson JP, Dumitru R, Coryell P, Baxley RM, Chen W, Twaroski K, Webber BR, Tolar J, Bielinsky AK, Purvis JE, Cook JG. Rapid DNA replication origin licensing protects stem cell pluripotency. Elife. 2017 Nov 17;6. pii: e30473. http://dx.doi.org/10.7554/eLife.30473. PMID: 29148972. PMCID: PMC5720591.
  23. Hinderer C, Katz N, Louboutin J-P, Bell P, Tolar J, Orchard PJ, Lund TC, Nayal M, Weng L, Mesaros C, deSouza C, Corte AD, Giugliani R, Wilson JM. Abnormal polyamine metabolism is unique to the neuropathic forms of MPS: Potential for biomarker development and insight into pathogenesis. Hum Mol Genet. 2017 26(19):3837-3849. http://dx.doi.org/10.1093/hmg/ddx277. PMID: 28934395. PMCID: PMC5886077. (UPenn Press Release 2017 Aug 8)
  24. Ivaturi V, Dvorak CC, Chan D, Liu T, Cowan MJ, Wahlstrom J, Stricherz M, Jennissen C, Orchard PJ, Tolar J, Pai SY, Huang L, Aweeka F, Long-Boyle J. Pharmacokinetics and model-based dosing to optimize fludarabine therapy in pediatric hematopoietic cell transplant recipients. Biol Blood Marrow Transplant. 2017 Oct;23(10):1701-1713. http://dx.doi.org/10.1016/j.bbmt.2017.06.021. PMID: 28684371.
  25. Ward E, Twaroski K, Tolar J. Feeder-free derivation of naïve human pluripotent stem cells. Stem Cells Dev. 2017 Aug;26(15):1087-89. http://dx.doi.org/10.1089/scd.2017.0067. PMID: 28537496. PMCID: PMC5563919.
  26. Magli A, Incitti T, Kiley J, Swanson SA, Darabi R, Rinaldi F, Selvaraj S, Yamamoto A, Tolar J, Yuan C, Stewart R, Thomson JA, Perlingeiro RCR. PAX7 targets, CD54, Integrin α9β1, and SDC2, allow isolation of human ESC/iPSC-derived myogenic progenitors. Cell Rep. 2017 Jun 27;19(13):2867-2877. http://dx.doi.org/10.1016/j.celrep.2017.06.005. PMID: 28658631. PMCID: PMC5528177.
  27. Skvarova Kramarzova K, Osborn MJ, Webber BR, DeFeo AP, McElroy AN, Kim CJ, Tolar J. CRISPR/Cas9-mediated correction of the FANCD1 gene in primary patient cells. Int J Mol Sci. 2017 Jun 14;18(6). pii: E1269. http://dx.doi.org/10.3390/ijms18061269. PMID: 28613254. PMCID: PMC5486091.
  28. Webber BR, O'Connor KT, McElmurry RT, Durgin EN, Eide CR, Lees CJ, Riddle MJ, Mathews WE, Frank NY, Kluth MA, Ganss C, Moriarity BS, Frank MH, Osborn MJ, Tolar J. Rapid generation of Col7a1-/- mouse model of recessive dystrophic epidermolysis bullosa and partial rescue via immunosuppressive dermal mesenchymal stem cells. Lab Invest. 2017 Oct;97(10):1218-1224. http://dx.doi.org/10.1038/labinvest.2017.85. PMID: 28892093. PMCID: PMC5623156.
  29. Dietz AC, Savage SA, Vlachos A, Mehta PA, Bresters D, Tolar J, Bonfim C, Dalle JH, de la Fuente J, Skinner R, Boulad F, Duncan CN, Baker KS, Pulsipher MA, Lipton JM, Wagner JE, Alter BP. Late effects screening guidelines after hematopoietic cell transplantation for inherited bone marrow failure syndromes: consensus statement from the Second Pediatric Blood and Marrow Transplant Consortium International Conference on Late Effects After Pediatric HCT. Biol Blood Marrow Transplant. 2017 Sep;23(9):1422-1428. http://dx.doi.org/10.1016/j.bbmt.2017.05.022. PMID: 28533057. PMCID: PMC5565711.
  30. Smith MJ, Reichenbach DK, Parker SL, Riddle MJ, Mitchell J, Osum KC, Mohtashami M, Stefanski HE, Fife BT, Bhandoola A, Hogquist KA, Holländer GA, Zúñiga-Pflücker JC, Tolar J, Blazar, BR. T cell progenitor therapy-facilitated thymopoiesis depends upon thymic input and continued thymic microenvironment interaction. JCI Insight. 2017 May 18;2(10)e92056. http://dx.doi.org/10.1172/jci.insight.92056. PMID: 28515359. PMCID: PMC5436538. 
  31. Knipping F, Osborn MJ, Petri K, Tolar J, Glimm H, von Kalle C, Schmidt M, Gabriel R. Genome-wide specificity of highly efficient TALENs and CRISPR/Cas9 for T cell receptor modification. Mol Ther Methods Clin Dev 2017 Feb 12;4:213-244. http://dx.doi.org/10.1016/j.omtm.2017.01.005. eCollection 2017 Mar 17. PMID: 28345006. PMCID: PMC5363317.
  32. Osborn MJ, Webber BR, McElmurry RT, Rudser KD, DeFeo AP, Muradian M, Petryk A, Hallgrimsson B, Blazar BR, Tolar J, Braunlin EA. Angiotensin receptor blockade mediated amelioration of mucopolysaccharidosis type I cardiac and craniofacial pathology. J Inherit Metab Dis. 2017 Mar;40(2):281-289. http://dx.doi.org/10.1007/s10545-016-9988-z. PMID: 27743312. PMCID: PMC5335863.
  33. Lee JY, Hsu CK, Michael M, Nanda A, Liu L, McMillan JR, Pourreyron C, Takeichi T, Tolar J, Reid E, Hayday T, Blumen SC, Abu-Mouch S, Straussberg R, Basel-Vanagaite L, Barhum Y, Zouabi Y, Al-Ajmi H, Huang HY, Lin TC, Akiyama M, Lee JY, McLean WH, Simpson MA, Parsons M, McGrath JA. Large intragenic deletion in DSTYK underlies autosomal-recessive complicated spastic paraparesis, SPG23. Am J Hum Genet. 2017 Feb 2; 100(2):364-370. http://dx.doi.org/10.1016/j.ajhg.2017.01.014. PMID: 28157540. PMCID: PMC5294675.
  34. Kramer AC, Weber J, Zhang Y, Tolar J, Gibbens YY, Shevik M, Lund TC. TP53 modulates oxidative stress in Gata+ erythroid cells. Stem Cell Reports. 2017 Jan 25. 8(2):360-372. http://doi.org/10.1016/j.stemcr.2016.12.025. PMID: 28132886. PMCID: PMC5312256.
  35. Mallhi K, Orchard PJ, Miller WP, Cao Q, Tolar J, Lund TC. Non-myeloablative conditioning for second hematopoietic cell transplantation for graft failure in patients with non-malignant disorders: A prospective study and review of the literature. Bone Marrow Transplant. 2017 Jan 16;52(5):726-732. http://dx.doi.org/10.1038/bmt.2016.356. PMID: 28092353. 
  36. Astuti Y, Kramer AC, Blake AL, Blazar BR, Tolar J, Taisto ME, Lund TC. A functional bioluminescent zebrafish screen for enhancing hematopoietic cell homing. Stem Cell Reports. 2017 Jan 10;8(1):177-190. http://dx.doi.org/10.1016/j.stemcr.2016.12.004. PMID: 28041876. PMCID: PMC5233450.
  37. Boyle WS, Senger K, Tolar J, Reineke TM. Heparin enhances transfection in concert with a trehalose-based polycation with challenging cell types. Biomacromolecules. 2017 Jan 9;18(1):56-67. http://dx.doi.org/10.1021/acs.biomac.6b01297. PMID: 27992192.
  38. Webber BR, Osborn MJ, McElroy AN, Twaroski K, Lonetree C, DeFeo AP, Xia L, Edie CJ, McElmurry RT, Riddle MJ, Kim CJ, Patel DD, Blazar BR, Tolar J. CRISPR/Cas9-based genetic correction for recessive dystrophic epidermolysis bullosa. npj Regen Med. 2016 Dec 8;1, Article #16014; http://dx.doi.org/10.1038/npjregenmed.2016.14. PMID: 28250968. PMCID: PMC5328670.
  39. Vanden Oever M, Muldoon D, Mathews W, McElmurry R, Tolar J. miR-29 regulates type VII collagen in recessive dystrophic epidermolysis bullosa. J Invest Dermatol. 2016 Oct;136(10):2013-21. http://dx.doi.org/10.1016/j.jid.2016.05.115. PMID: 27328306. PMCID: PMC5341382.
  40. Hippen KL, Watkins B, Tkachev V, Lemire AM, Lehnen C, Riddle MJ, Singh K, Panoskaltsis-Mortari A, Vanhove B, Tolar J, Kean LS, Blazar BR. Preclinical testing of anti-human CD28 Fab' antibody in a novel nonhuman primate (NHP) small animal rodent model of xenogenic graft-versus-host disease (GVHD). Transplantation. 2016 Sep;100(12):2630-9. http://dx.doi.org/10.1097/TP.0000000000001465. PMID: 27607527. PMCID: PMC5175408.
  41. Osborn M, Lonetree CL, Webber BR, Patel D, Dunmire S, McElroy AN, DeFeo AP, MacMillan ML, Wagner J, Blazar BR, Tolar J. CRISPR/Cas9 targeted gene editing and cellular engineering in Fanconi anemia. Stem Cells Dev. 2016 Aug;25(20):1591-603. http://dx.doi.org/10.1089/scd.2016.0149. PMID: 27538887. PMCID: PMC5059216.
  42. Vallera DA, Felices M, McElmurry RT, McCullar V, Zhou X, Schmohl J, Zhang B, Lenvik A, Panoskaltsis-Mortari A, Verneris MR, Tolar J, Cooley S, Weisdorf D, Blazar BR, Miller JS. IL-15 trispecific killer engagers (TriKEs) make natural killer cells specific to CD33+ targets while also inducing in vivo expansion, and enhanced function. Clin Cancer Res. 2016 Jul 15;22(14):3440-50. http://dx.doi.org/10.1158/1078-0432.CCR-15-2710. PMID: 26847056. PMCID: PMC4947440.
  43. Yuan C, Bothun ED, Hardten DR, Tolar J, McLoon LK. A novel explanation of corneal clouding in a bone marrow transplant-treated patient with Hurler syndrome. Exp Eye Res. 2016 Jul;148:83-9. http://dx.doi.org/10.1016/j.exer.2016.05.022. PMID: 27235795.
  44. Lindborg BA, Brekke JH, Vegoe AL, Ulrich CB, Haider KT, Subramaniam S, Venhuizen SL, Eide CR, Orchard PJ, Chen W, Wang Q, Pelaez F, Scott CM, Kokkoli E, Keirstead SA, Dutton JR, Tolar J*, O'Brien TD* (*co-last authors). Rapid induction of cerebral organoids from human induced pluripotent stem cells using a chemically defined hydrogel and defined cell culture medium. Stem Cells Transl Med. 2016 Jul;5(7):970-9. http://dx.doi.org/10.5966/sctm.2015-0305. PMID: 27177577. PMCID: PMC4922855.
  45. Boull CL, Hylwa SA, Sajic D, Wagner JE, Tolar J, Hook KP. Toxic epidermal necrolysis in recessive dystrophic epidermolysis bullosa following bone marrow transplantation. J Pediatr. 2016 Jun;173:242-4. http://dx.doi.org/10.1016/j.jpeds.2016.02.037. PMID: 26976809.
  46. Thibert KA, Raymond GV, Tolar J, Miller WP, Orchard PJ, Lund TC. Cerebral spinal fluid levels of cytokines are elevated in patients with metachromatic leukodystrophy. Sci Rep. 2016 Apr 15;6:24579. http://dx.doi.org/10.1038/srep24579. PMID: 27079147. PMCID: PMC4832325.
  47. Agrawal P, Ingle N, Boyle W, Ward E, Tolar J, Dorfman K, Reineke T. Fast, efficient and gentle transfection of human adherent cells in suspension. ACS Appl Mater Interfaces. 2016 Apr 13;8(14):8870-4. http://dx.doi.org/10.1021/acsami.6b01702. PMID: 27035392.
  48. Ghosh A, Miller W, Orchard PJ, Jones SA, Mercer J, Church HJ, Tylee K, Lund T, Bigger BW, Tolar J, Wynn RF. Enzyme replacement therapy prior to haematopoietic stem cell transplantation in mucopolysaccharidosis type I: 10 year combined experience of 2 centres. Mol Genet Metab. 2016 Mar;117(3):373-7. http://dx.doi.org/10.1016/j.ymgme.2016.01.011. PMID: 26832957.
  49. Kunin-Batson AS, Shapiro EG, Rudser KD, Lavery CA, Bjoraker KJ, Jones SA, Wynn RF, Vellodi A, Tolar J, Orchard PJ, Wraith JE. Long-term cognitive and functional outcomes in children with mucopolysaccharidosis (MPS)-IH (Hurler syndrome) treated with hematopoietic cell transplantation. JIMD Rep. 2016;29:95-102. http://dx.doi.org/10.1007%2F8904_2015_521. PMID: 26825088. PMCID: PMC5059216.
  50. Wagner JE Jr, Brunstein CG, Boitano AE, DeFor TE, McKenna D, Sumstad D, Blazar BR, Tolar J, Le C, Jones J, Cooke MP, Bleul C. Phase I/II trial of StemRegenin-1 expanded umbilical cord blood hematopoietic stem cells supports testing as a stand-alone graft. Cell Stem Cell. 2016 Jan 7; 18(1):144-55. http://dx.doi.org/10.1016/j.stem.2015.10.004. PMID: 26669897. PMCID: PMC4881386.
  51. Osborn MJ*, Webber BR*, Knipping F*, Lonetree CL, Tennis N, DeFeo AP, McElroy AN, Starker CG, Lee C, Gabriel R, Merkel S, Lund TC, Kelly-Spratt KS, Jensen MC, Voytas DF, von Kalle C, Schmidt M, Hippen KL, Miller JS, Scharenberg AM*, Tolar J*, Blazar BR* (*equal contributors). Evaluation of TCR gene editing achieved by TALENs, CRISPR/Cas9 and megaTAL nucleases. Mol Ther. 2016 Mar;24(3):570-81. http://dx.doi.org/10.1038/mt.2015.197. PMID: 26502778. PMCID: PMC4786913.
  52. Poynter JN, Bestrashniy JR, Silverstein KA, Hooten AJ, Lees C, Ross JA, Tolar J. Cross platform analysis of methylation, miRNA and stem cell gene expression data in germ cell tumors highlights characteristic differences by tumor histology. BMC Cancer. 2015 Oct 23;15:769. http://dx.doi.org/10.1186/s12885-015-1796-6. PMID: 26497383. PMCID: PMC4619074.
  53. Kitajima K, Nakajima M, Kanokoda M, Kyba M, Dandapat A, Tolar J, Saito MK, Toyoda M, Umezawa A, Hara T. GSK3β inhibition activates the CDX/HOX pathway and promotes hemogenic endothelial progenitor differentiation from human pluripotent stem cells. Exp Hematol. 2016 Jan;44(1):68-74.e1-10. http://dx.doi.org/10.1016/j.exphem.2015.09.007. PMID: 26477526. 
  54. Anderlini P, Wu J, Gersten I, Ewell M, Tolar J, Antin JH, Adams R, Arai S, Eames G, Horwitz ME, McCarty J, Nakamura R, Pulsipher MA, Rowley S, Leifer E, Carter SL, DiFronzo NL, Horowitz MM, Confer D, Deeg HJ, Eapen M. Cyclophosphamide conditioning in patients with severe aplastic anaemia given unrelated marrow transplantation: a phase 1-2 dose de-escalation study. Lancet Haematol. 2015 Sep;2(9):e367-75. http://dx.doi.org/10.1016/S2352-3026(15)00147-7. PMID: 22546497. PMCID: PMC3677744.
  55. Lund TC, Liegel J, Bejanyan N, Orchard PJ, Cao Q, Tolar J, Brunstein C, Wagner JE, Verneris MR, Weisdorf D. Second allogeneic hematopoietic cell transplantation for graft failure: Poor outcomes for neutropenic graft failure. Am J Hematol. 2015 Sep;90(10):892-6. http://dx.doi.org/10.1002/ajh.24111. PMID: 26149534. PMCID: PMC4579006.
  56. Watt S, Dayal J, Wright S, Pourreyron C, McMillan J, Riddle M, McLean I, Leigh I, McGrath J, Salas-Alanis J, Tolar J, South AP. Lysyl hydroxylase 3 localizes to epidermal basement membrane and is reduced in patients with recessive dystrophic epidermolysis bullosa. PLoS One. 2015 Sep 18;10(9):e0137639. http://dx.doi.org/10.1371/journal.pone.0137639. PMID: 26380979. PMCID: PMC4575209.
  57. Koehn BH, Apostolova P, Haverkamp JM, Miller JS, McCullar V, Tolar J, Munn DH, Murphy WJ, Brickey WJ, Serody JS, Gabrilovich DI, Bronte V, Murray PJ, Ting JP, Zeiser R, Blazar BR. GvHD-associated, inflammasome-mediated loss of function in adoptively transferred myeloid-derived suppressor cells. Blood. 2015 Sep;126(13):1621-8. http://dx.doi.org//10.1182/blood-2015-03-634691. PMID: 26265697. PMCID: PMC4582338.
  58. Modiano JF, Lindborg BA, McElmurry RT, Lewellen M, Forster CL, Zamora EA, Schaack J, Bellgrau D, O'Brien TD, Tolar J. Mesenchymal stromal cells inhibit murine syngeneic anti-tumor immune responses by attenuating inflammation and reorganizing the tumor microenvironment. Cancer Immunol Immunother. 2015 Nov;64(11):1449-60. http://dx.doi.org/10.1007/s00262-015-1749-6. PMID: 26250807. PMCID: PMC4618101.
  59. Aldenhoven M, Wynn RF, Orchard PJ, O’Meara A, Veys P, Fischer A, Valayannopoulos V, Neven B, Rovelli A, Prasad VK, Tolar J, Allewelt H, Jones SA, Parini R, Renard M, Bordon V, Wulffraat NM, de Koning TJ, Shapiro, EC, Kurtzberg J, Boelens JJ. Long-term outcome of Hurler syndrome patients after hematopoietic cell transplantation: an international multi-center study. Blood. 2015 Mar;125(13)2164-72. http://dx.doi.org/10.1182/blood-2014-11-608075. PMID: 25624320. 
  60. Osborn MJ, Gabriel R, Webber BR, DeFeo AP, McElroy AN, Jarjour J, Starker CG, Wagner JE, Joung JK, Voytas DF, von Kalle C, Schmidt M, Blazar BR, Tolar J. Fanconi anemia gene editing by the CRISPR/Cas9 system. Hum Gene Ther. 2015 Feb;26(2):114-26. http://dx.doi.org/10.1089/hum.2014.111. PMID: 25545896. PMCID: PMC4326027.
  61. Petrof G, Lwin SM, Martinez-Queipo M, Abdul-Wahab A, Tso S, Mellerio JE, Slaper-Cortenbach I, Boelens JJ, Tolar J, Veys P, Ofuya M, Peacock JL, Martinez AE, McGrath JA. Potential of systemic allogeneic mesenchymal stromal cell therapy for children with recessive dystrophic epidermolysis bullosa. J Invest Dermatol. 2015 Sep;135(9):2319-21. http://dx.doi.org/10.1038/jid.2015.158. PMID: 25905587. PMCID: PMC5696540.
  62. Dickson PI, Tolar J. The individual (single patient) IND for inborn errors of metabolism. Mol Genet Metab. 2015 Sep-Oct;116(1-2):1-3. http://dx.doi.org/10.1016/j.ymgme.2014.10.003. PMID: 25456747. 
  63. Mack MR, Wendelschafer-Crabb G, McAdams B, Hordinsky M, Kennedy W, Tolar J. Peripheral neuro-immune pathology in recessive dystrophic epidermolysis bullosa. J Invest Dermatol. 2015 Apr;135(4):1193-7. http://dx.doi.org/10.1038/jid.2014.500. PMID: 25431850. PMCID: PMC4366323.
  64. Zhang L, Guo J, Zhang P, Xiong Q, Wu SC, Xia L, Roy SS, Tolar J, O'Connell TD, Kyba M, Liao K, Zhang J. Derivation and high engraftment of patient-specific cardiomyocyte-sheet using induced pluripotent stem cells generated from adult cardiac fibroblast. Circ Heart Fail. 2015 Jan;8(1):156-66. http://dx.doi.org/10.1161/CIRCHEARTFAILURE.114.001317. PMID: 25420485. PMCID: PMC4303534.
  65. Ross JA, Tolar J, Spector LG, DeFor T, Lund TC, Weisdorf DJ, Langer E, Hooten AJ, Thyagarajan B, Gleason MK, Wagner JE, Robien K, Verneris MR. An exploratory analysis of mitochondrial haplotypes and allogeneic hematopoietic cell transplantation (HCT) outcomes. Biol Blood Marrow Transplant. 2015;21(1):81-8. http://dx.doi.org/10.1016/j.bbmt.2014.09.023. PMID: 25300867. PMCID: PMC4272903.
  66. Perdoni C, McGrath JA, Tolar J. Preconditioning of mesenchymal stem cells for improved transplantation efficacy in recessive dystrophic epidermolysis bullosa. Stem Cell Res Ther. 2014 Nov 6;5(6):121. http://dx.doi.org/10.1186/scrt511. PMID: 25376815. PMCID: PMC4446116.
  67. Raza K, Larsen T, Samaratunga N, Price AP, Meyer C, Matson A, Ehrhardt MJ, Fogas S, Tolar J, Hertz MI, Panoskaltsis-Mortari A. MSC therapy attenuates obliterative bronchiolitis after murine bone marrow transplant. PLoS One. 2014 Oct 1;9(10):e109034. http://dx.doi.org/10.1371/journal.pone.0109034. PMID: 25272285. PMCID: PMC4182803.
  68. Poynter JN, Fonstad R, Tolar J, Spector LG, Ross JA. Incidence of intracranial germ cell tumors by race in the United States, 1992-2010. J Neurooncol. 2014; 120(2):381-8. http://dx.doi.org/10.1007/s11060-014-1562-7. PMID: 25086758. PMCID: PMC4206671.
  69. Lund TC, Patrinostro X, Kramer AC, Stadem P, Higgins L, Markowski TW, Wroblewski MS, Lidke DS, Tolar J, Blazar BR. sdf1 Expression reveals a source of perivascular-derived mesenchymal stem cells in zebrafish. Stem Cells. 2014 Oct;32(10):2767-79. http://dx.doi.org/10.1002/stem.1758. PMID: 24905975. PMCID: PMC4165765
  70. Miller JS, Rooney CM, Curtsinger J, McElmurry R, McCullar V, Verneris MR, Lapteva N, McKenna D, Wagner JE, Blazar BR, Tolar J. Expansion and homing of adoptively transferred human natural killer cells in immunodeficient mice varies with product preparation and in vivo cytokine administration: implications for clinical therapy. Biol Blood Marrow Transplant. 2014 Aug;20(8):1252-7. http://dx.doi.org/10.1016/j.bbmt.2014.05.004. PMID: 24816582. PMCID: PMC4099265.
  71. Tolar J, McGrath JA, Xia L, Riddle M, Lees CJ, Eide C, Keene DR, Liu L, Osborn MJ, Lund TC, Blazar BR, Wagner JE. Patient-specific naturally gene-reverted induced pluripotent stem cells in recessive dystrophic epidermolysis bullosa. J Invest Dermatol. 2014 May;134(5):1246-54. http://dx.doi.org/10.1038/jid.2013.523. PMID: 24317394. PMCID: PMC3989384. 
  72. Tolar J, Wagner JE. Allogeneic blood and bone marrow cells for the treatment of severe epidermolysis bullosa: repair of the extracellular matrix. Lancet. 2013 Oct 5;382(9899):1214-23. http://dx.doi.org/10.1016/s0140-6736(13)61897-8. PMID: 24095195. PMCID: PMC3959900.
  73. Webber BR, Iacovino M, Choi SH, Tolar J*, Kyba M*, Blazar BR* (*equal contributors). DNA methylation of Runx1 regulatory regions correlates with transition from primitive to definitive hematopoietic potential in vitro and in vivo. Blood. 2013 Oct;122(17):2978-86. http://dx.doi.org/10.1182/blood-2013-03-489369. PMID: 24030384. PMCID: PMC3811172. 
  74. Aoyama K, Saha A, Tolar J, Riddle MJ, Veenstra RG, Taylor PA, Blomhoff R, Panoskaltsis-Mortari A, Klebanoff CA, Socie G, Munn DH, Murphy WJ, Serody JS, Fulton L, Teshmia T, Chandraratna RA, Dmitrovsky E, Guo Y, Blazar BR. Inhibiting retinoic acid signaling ameliorates graft-versus-host disease by modifying T-cell differentiation and intestinal migration. Blood. 2013 Sept 19;122(12):2125-34. http://10.1182/blood-2012-11-470252. PMID: 23814022. PMCID: PMC3778553. 
  75. Gadalla SM, Sales-Bonfim C, Carreras J, Alter BP, Antin JH, Ayas M, Bodhi P, Davis J, Davies SM, Deconinck E, Deeg HJ, Duerst RE, Fasth A, Ghavamzadeh A, Giri N, Goldman FD, Kolb EA, Krance R, Kurtzberg J, Leung WH, Srivastava A, Or R, Richman CM, Rosenberg PS, Toledo Codina JS, Shenoy S, Socié G, Tolar J, Williams KM, Eapen M, Savage SA. Outcomes of allogeneic hematopoietic cell transplantation in patients with dyskeratosis congenita. Biol Blood Marrow Transplant. 2013 Aug;19(8):1238-43. http://dx/doi.org/10.1016/j.bbmt.2013.05.021. PMID: 23751955. PMCID: PMC3736557.
  76. Thawrani DP, Walker K, Polgreen LE, Tolar J*, Orchard PJ* (*equal contributors). Hip dysplasia in patients with Hurler syndrome (Mucopolysaccharidosis type 1H). J Pediatr Orthop. 2013 Sep;33(6):635-43. http://10.1097/bpo.0b013e31829abfe0. PMID: 23812141. 
  77. Osborn MJ, Starker CG, McElroy AN, Webber BR, Riddle MJ, Xia L, DeFeo AP, Gabriel R, Schmidt M, von Kalle C, Carlson DF, Maeder ML, Joung JK, Wagner JE, Voytas DF, Blazar BR, Tolar J. TALEN-based gene correction for epidermolysis bullosa. Mol Ther. 2013 Jun;21(6):1151-9. PMID: 23546300. PMCID: PMC3677309. Commentary “Enzymes fix disease genes” in Nature, vol 497, May 2, 2013. http://dx.doi.org/10.1038/mt.2013.56. This ranks 3rd in the top 7 papers in Molecular Therapy, http://crosstalk.cell.com/blog/7-molecular-therapy-classics-to-read-for-....
  78. Lund TC, Kobs AJ, Kramer A, Nyquist M, Kuroki MT, Osborn J, Lidke DS, Low-Nam ST, Blazar BR, Tolar J. Bone marrow stromal and vascular smooth muscle cells have chemosensory capacity via bitter taste receptor expression. PLoS One. 2013;8(3):e58945. http://dx.doi.org/10.1371/journal.pone.0058945. PMID: 23520545. PMCID: PMC3592821.
  79. Boelens JJ, Aldenhoven M, Purtill D, Ruggeri A, DeFor T, Wynn R, Wraith E, Cavazzana-Calvo M, Rovelli A, Fischer A, Tolar J, Prasad VK, Escolar M, Gluckman E, O'Meara A, Orchard PJ, Veys P, Eapen M, Kurtzberg J, Rocha V. Outcomes of transplantation using various hematopoietic cell sources in children with Hurler's syndrome after myeloablative conditioning. Blood. 2013 May 9;121(19):3981-7. Cited by Hematopoiesis News 4.10 March 19, 2013. http://dx.doi.org/10.1182/blood-2012-09-455238. PMID: 23493783. PMCID: PMC3836041.
  80. Aldoss O, Gruenstein DH, Bass JL, Steinberger J, Zhang Y, DeFor TE, Tolar J, Verneris MR, Orchard PJ. Pericardial effusion after pediatric hematopoietic cell transplant. Pediatr Transplant. 2013 May;17(3):294-9. http://dx.doi.org/10.1111/petr.12062. PMID: 23464863.
  81. Eisengart JB, Rudser KD, Tolar J, Orchard PJ, Kivisto T, Ziegler RS, Whitley CB, Shapiro EG. Enzyme replacement is associated with better cognitive outcomes after transplant in Hurler syndrome. J Pediatr. 2013 Feb;162(2):375-80. http://dx.doi.org/10.1016/j.ipeds.2012.07.052. PMID: 22974573. PMCID: PMC3524404.
  82. Schroeder L, Orchard P, Whitley CB, Berry JM, Tolar J, Miller W, Braunlin EA. Cardiac ultrasound findings in infants with severe (Hurler phenotype) untreated mucopolysaccharidosis (MPS) type I. JIMD Rep. 2013;10:87-94. http://dx.doi.org/10.1007/8904_2012_182. PMID: 23430808. PMCID: PMC3755584.
  83. Thibert KA, Raymond GV, Nascene DR, Miller WP, Tolar J, Orchard PJ, Lund TC. Cerebrospinal fluid matrix metalloproteinases are elevated in cerebral adrenoleukodystrophy and correlate with MRI severity and neurologic dysfunction. PLoS One. 2012;7(11):e50430. http://dx.doi.org/10.1371/journal.pone.0050430. PMID: 23185624. PMCID: PMC3503955.
  84. Szaboova A, Kuzelka O, Zelezny F, Tolar J. Prediction of DNA-binding proteins from relational features. Proteome Sci. 2012 Nov 12;10(1):66. http://dx.doi.org/10.1186/1477-5956-10-66. PMID: 23146001.
  85. Tolar J, Xia L, Lees CJ, Riddle M, McElroy A, Keene DR, Lund TC, Osborn MJ, Marinkovich MP, Blazar BR, Wagner JE. Keratinocytes from induced pluripotent stem cells in junctional epidermolysis bullosa. J Invest Dermatol. 2013 Feb;133(2):592-5. http://dx.doi.org/10.1038/jid.2012.278. PMID: 22931927. PMCID: PMC3514565.
  86. McKinney AM, Nascene D, Miller WP, Eisengart J, Loes D, Benson M, Tolar J, Orchard PJ, Ziegler RS, Zhang L, Provenzale J. Childhood cerebral X-linked adrenoleukodystrophy: Diffusion tensor imaging measurements for prediction of clinical outcome after hematopoietic stem cell transplantation. Am J Neuroradiol. 2013 Mar;34(3):641-9. http://dx.doi.org/10.3174/ajnr.A3232. PMID: 22899791.
  87. Shapiro E, Guler OE, Rudser K, Delaney K, Bjoraker K, Whitley C, Tolar J, Orchard P, Provenzale J, Thomas KM. An exploratory study of brain function and structure in mucopolysaccharidosis type I: Long term observations following hematopoietic cell transplantation (HCT). Mol Genet Metab. 2012 Sep;107(1-2)L116-21. http://dx.doi.org/10.1016/j.ymgme.2012.07.016. PMID: 22867884. PMCID: PMC3444648.
  88. Tolar J, Deeg HJ, Arai S, Horwitz M, Antin JH, McCarty JM, Adams RH, Ewell M, Leifer ES, Gersten ID, Carter SL, Horowitz MM, Nakamura R, Pulsipher MA, Difronzo NL, Confer DL, Eapen M, Anderlini P. Fludarabine-based conditioning for marrow transplantation from unrelated donors in severe aplastic anemia: early results of a cyclophosphamide dose deescalation study show life-threatening adverse events at predefined cyclophosphamide dose levels. Biol Blood Marrow Transplant. 2012 Jul;18(7):1007-11. http://dx.doi.org/10.1016/j.bbmt.2012.04.014. PMID: 22546497. PMCID: PMC3677744.
  89. Lund TC, Stadem PS, Panoskaltsis-Mortari A, Raymond G, Miller WP, Tolar J, Orchard PJ. Elevated cerebral spinal fluid cytokine levels in boys with cerebral adrenoleukodystrophy correlates with MRI severity. PLoS One. 2012;7(2):e32218. http://dx.doi.org/10.1371/journal.pone.0032218. PMID: 22359672. PMCID: PMC3281135.
  90. Kim H, Long-Boyle J, Rydholm N, Orchard PJ, Tolar J, Smith AR, Jacobson P, Brundage R. Population pharmacokinetics of unbound mycophenolic acid in pediatric and young adult patients undergoing allogeneic hematopoietic cell transplantation. J Clin Pharmacol. 2012 Nov;52(11):1665-75. http://dx.doi.org/10.1177/0091270011422814. PMID: 22110162
  91. Mynarek M, Tolar J, Albert MH, Escolar ML, Boelens JJ, Cowan MJ, Finnegan N, Glomstein A, Jacobsohn DA, Kühl JS, Yabe H, Kurtzberg J, Malm D, Orchard PJ, Klein C, Lücke T, Sykora KW. Allogeneic hematopoietic SCT for alpha-mannosidosis: an analysis of 17 patients. Bone Marrow Transplant. 2012 Mar;47(3):352-9. http://dx.doi.org/10.1177/0091270011422814. PMID: 21552297. 
  92. Dolan M, Cioc A, Cross NC, Neglia JP, Tolar J. Favorable outcome of allogeneic hematopoietic cell transplantation for 8p11 myloproliferative syndrome associated with BCR-FGFR1 gene fusion. Pediatr Blood Cancer. 2012 Jul 15;59(1):194-6. http://dx.doi.org/10.1002/pbc.23404. PMID: 22106025. 
  93. Orchard PJ, Lund T, Miller W, Rothman SM, Raymond G, Nascene D, Basso L, Cloyd J, Tolar J. Chitotriosidase as a biomarker of cerebral adrenoleukodystrophy. J Neuroinflammation. 2011 Oct 20;8:144. http://dx.doi.org/10.1186/1742-2094-8-144. PMID: 22014002. PMCID: PMC3236018.
  94. Lund TC, Glass TJ, Somani A, Nair S, Tolar J, Nyquist M, Patrinostro X, Blazar BR. Zebrafish stromal cells have endothelial properties and support hematopoietic cells. Exp Hematol. 2012 Jan;40(1):61-70e1. http://dx.doi.org/10.1016/j.exphem.2011.09.005. PMID: 21920471. PMCID: PMC4106246. 
  95. Hyland KA, Olson ER, Clark KJ, Aronovich EL, Hackett PB, Blazar BR, Tolar J, Scott McIvor R. Sleeping Beauty-mediated correction of Fanconi anemia type C. J Gene Med. 2011 Sep;13(9):462-9. http://dx.doi.org/10.1002/jgm.1589. PMID: 21766398. 
  96. Greising SM, Call JA, Lund TC, Blazar BR, Tolar J, Lowe DA. Skeletal muscle contractile function and neuromuscular performance in Zmpste24 (-/-) mice, a murine model of human progeria. Age (Dordr). 2012 Aug;34(4):805-19. http://dx.doi.org/10.1007/s11357-011-9281-x. PMID: 21713376. PMCID: PMC3682066.
  97. Eapen M, Le Rademacher J, Antin JH, Champlin RE, Carreras J, Fay J, Passweg JR, Tolar J, Horowitz MM, Marsh JC, Deeg HJ. Effect of stem cell source on outcomes after unrelated donor transplantation in severe aplastic anemia. Blood. 2011 Sep 1;118(9):2618-21. http://dx.doi.org/10.1182/blood-2011-05-354001. PMID: 21677312. PMCID: PMC3167362.
  98. Osborn MJ, DeFeo AP, Blazar B*, Tolar J* (*co-last authors). Synthetic zinc finger nuclease design and rapid assembly. Hum Gene Ther. 2011 Sep;22(9):1155-65. http://dx.doi.org/10.1089/hum.2011.072. PMID: 21663559. PMCID: PMC4076977.
  99. Glass TJ, Lund TC, Patrinostro X, Tolar J, Bowman TV, Zon LI, Blazar BR. Stromal cell-derived factor-1 (SDF-1) and hematopoietic cell homing in an adult zebrafish model of hematopoietic cell transplant. Blood. 2011 Jul 21;118(3):766-74. http://dx.doi.org/10.1182/blood-2011-01-328476. PMID: 21622651. PMCID: PMC3292438.
  100. Miller WP, Rothman SM, Nascene D, Kivisto T, DeFor TE, Ziegler RS, Eisengart J, Leiser K, Raymond G, Lund TC, Tolar J*, Orchard PJ* (*co-last authors). Outcomes after allogeneic hematopoietic cell transplantation for childhood cerebral adrenoleukodystrophy: the largest single-institutional cohort report. Blood. 2011 Aug 18;118(7):1971-8. http://dx.doi.org/10.1182/blood-2011-01-329235. PMID: 21586746.
  101. Zhang H, Young SP, Auray-Blais C, Orchard PJ, Tolar J, Millington DS. Analysis of glycosaminoglycans in cerebrospinal fluid from patients with mucopolysaccharidoses by isotope-dilution ultra-performance liquid chromatography/tandem mass spectrometry. Clin Chem. 2011 Jul;57(7):1005-12. http://dx.doi.org/10.1373/clinchem.2010.161141. PMID: 21576268. 
  102. Polgreen LE, Chahla S, Miller W, Rothman S, Tolar J, Kivisto T, Nascene D, Orchard PJ, Petryk A. Early diagnosis of cerebral X-linked adrenoleukodystrophy in boys with Addison’s disease improves survival and neurological outcomes. Eur J Pediatr. 2011 Aug;170(8):1049-54. http://dx.doi.org/10.1007/s00431-011-1401-1. PMID: 21279382. PMCID: PMC3101278.
  103. Heinecke KA, Peacock BN, Blazar BR, Tolar J*, Seyfried TN* (*co-last authors). Lipid composition of whole brain and cerebellum in Hurler syndrome (MPS IH) mice. Neurochem Res. 2011 Sep;36(9):1669-76. http://dx.doi.org/10.1007/s11064-011-0400-y. PMID: 21253856.
  104. Tolar J, Xia L, Riddle M, Lees CJ, Eide C, McElmurry RT, Titeux M, Osborn MJ, Lund TC, Hovnanian A, Wagner JE, Blazar BR. Induced pluripotent stem cells from individuals with recessive dystrophic epidermolysis bullosa. J Invest Dermatol. 2011 Apr;131(4):848-56. http://dx.doi.org/10.1038/jid.2010.346. PMID: 21124339. PMCID: PMC4151825.
  105. Osborn MJ, McElmurry RT, Lees CJ, DeFeo AP, Chen ZY, Kay MA, Naldini L, Freeman G, Tolar J*, Blazar BR* (*co-last authors). Minicircle DNA-based gene therapy coupled with immune modulation permits long-term expression of α-L-iduronidase in mice with mucopolysaccharidosis Type I. Mol Ther. 2011 Mar;19(3):450-60. http://dx.doi.org/10.1038/mt.2010.249. PMID: 21081900. PMCID: PMC3048178.
  106. Palpant NJ, Bedada FB, Peacock B, Blazar BR, Metzger JM, Tolar J. Cardiac disease in mucopolysaccharidosis type I attributed to catecholaminergic and hemodynamic deficiencies. Am J Physiol Heart Circ Physiol. 2011 Jan;300(1):H356-65. http://dx.doi.org/10.1152/ajpheart.00774.2010. PMID: 21076027. PMCID: PMC3023247.
  107. Tolar J, Park IH, Xia L, Lees CJ, Peacock B, Webber B, McElmurry RT, Eide CR, Orchard PJ, Kyba M, Osborn MJ, Lund TC, Wagner JE, Daley GQ, Blazar BR. Hematopoietic differentiation of induced pluripotent stem cells from patients with mucopolysaccharidosis type I (Hurler syndrome). Blood. 2011 Jan 20;117(3):839-47. http://dx.doi.org/10.1182/blood-2010-05-287607. PMID: 21037085. PMCID: PMC3035077.
  108. Pulsipher MA, Young NS, Tolar J, Risitano AM, Deeg HJ, Anderlini P, Calado R, Kojima S, Eapen M, Harris R, Scheinberg P, Savage S, Maciejewski JP, Tiu RV, Difronzo N, Horowitz MM, Antin JH. Optimization of therapy for severe aplastic anemia based on clinical, biological and treatment response parameters: conclusions of an International Working Group on Severe Aplastic Anemia convened by the Blood and Marrow Transplant Clinical Trials Network, March 2010. Biol Blood Marrow Transplant. 2011 Mar;17(3):291-9. http://dx.doi.org/10.1016/j.bbmt.2010.10.028. PMID: 21034841. PMCID: PMC3053041.
  109. Smith AR, Gulbahce E, Burke MJ, Cao Q, MacMillan ML, Tolar J, Orchard PJ, Blazar BR, Baker KS, Wagner JE, Verneris MR. Lower leukemia relapse in pediatric patients with pulmonary cytolytic thrombi following allogeneic transplant. Bone Marrow Transplant. 2011 Mar;46(3):368-71. http://dx.doi.org/10.1038/bmt.2010.119. PMID: 20548337. PMCID: PMC3556271.
  110. Wagner JE, Ishida-Yamamoto A, McGrath JA, Hordinsky M, Keene DR, Woodley DT, Chen M, Osborn MJ, Lund T, Dolan M, Blazar BR*, Tolar J* (BRB and JT contributed equally to this work). Bone marrow transplantation for recessive dystrophic epidermolysis bullosa. N Engl J Med. 2010 Aug 12;363(7):629-39. Quoted in the Faculty 1000. http://dx.doi.org/10.1056/nejmoa0910501. PMID: 20818854. PMCID: PMC2967187. 
  111. Highfill SL, Rodriguez PC, Zhou Q, Goetz CA, Veenstra RG, Taylor PA, Panoskaltsis-Mortari A, Serody JS, Munn DH, Tolar J, Ochoa AC, Blazar BR. Bone marrow myeloid-derived suppressor cells (MSCD) inhibit graft-versus-host disease (GVHD) via an arginase 1-dependent mechanism that is upregulated by IL-13. Blood. 2010 Dec 16;116(25):5738-47. http://dx.doi.org/10.1182/blood-2010-06-287839. PMID: 20807889. PMCID: PMC3031417.
  112. Lund TC, Kobs A, Blazar BR, Tolar J. Mesenchymal stromal cells from donors varying widely in age are of equal cellular fitness after in vitro expansion under hypoxic conditions. Cytotherapy. 2010 Dec;12(8):971-81. http://dx.doi.org/10.3109/14653249.2010.509394 PMID: 20807020. PMCID: PMC3657201. 
  113. Braunlin E, Tolar J, Mackey-Bojack S, Masinde T, Krivit W, Schoen FJ. Clear cells in the atrioventricular valves of infants with severe human mucopolysaccharidosis (Hurler syndrome) are activated valvular interstitial cells. Cardiovasc Pathol. 2011 Sep-Oct;20(5):315-21. http://dx.doi.org/10.1016/j.carpath.2010.06.004. PMID: 20619689. 
  114. Bothun ED, Decanini A, Summers CG, Orchard PJ, Tolar J. Outcome of penetrating keratoplasty for mucopolysaccharidoses. Arch Ophthalmol. 2011 Feb;47(3):352-9. http://dx.doi.org/10.1001/archophthalmol.2010.341. PMID: 21552297.
  115. Zhou Q, Munger ME, Highfill, SL, Tolar J, Weigel BJ, Riddle M, Sharpe AH, Vallera DA, Azuma M, Levine BL, June CH, Murphy WJ, Munn DH, Blazar BR. Program death-1 (PD-1) signaling and regulatory T cells (Tregs) collaborate to resist the function of adoptively transferred cytotoxic T lymphocytes (CTLs) in advanced acute myeloid leukemia (AML). Blood. 2010 Oct 7;116(14):2484-93. http://dx.doi.org/10.1182/blood-2010-03-275446. PMID: 20570856. PMCID: PMC2953885. 
  116. Long-Boyle J, Huang J, Rydholm N, Smith A, Orchard P, Tolar J, Jacobson P. Pharmacokinetics of clofarabine in patients with high-risk inherited metabolic disorders undergoing brain-sparing hematopoietic cell transplantation. J Clin Pharmacol. 2011 May;51(5):679-86. http://dx.doi.org/10.1177/0091270010372519. PMID: 20525919.
  117. Dietz AC, Orchard P, Baker KS, Giller R, Savage S, Alter B, Tolar J. Disease-specific hematopoietic cell transplantation: nonmyeloablative conditioning regimen for dyskeratosis congenita. Bone Marrow Transplant. 2011 Jan;46(1):98-104. http://dx.doi.org/10.1038/bmt.2010.65. PMID: 20383216.
  118. Arbuckle JH, Medveczky MM, Luka J, Hadley SH, Luegmayr A, Ablashi D, Lund TC, Tolar J, De Meirleir K, Montoya JG, Komaroff AL, Ambros PF, Medveczky PG. The latent human herpesvirus-6A genome specifically integrates in telomeres of human chromosomes in vivo and in vitro. Proc Natl Acad Sci USA. 2010 Mar 23;107(12):5563-8. http://dx.doi.org/10.1073/pnas.0913586107. PMID: 20212114. PMCID: PMC2851814.
  119. Beck JC, Burke MJ, Tolar J. Response of refractory immune thrombocytopenia after bone marrow transplantation to romiplostim. Ped Blood Cancer. 2010 Mar;54(3):490-1. http://dx.doi.org/10.1002/pbc.22332. PMID: 19908296.
  120. Orchard PJ, Tolar J, Transplant outcomes in leukodystrophies. Semin Hematol. 2010 Jan;47(1):70-8. http://dx.doi.org/10.1053/j.seminhematol.2009.10.006. PMID: 20109614.
  121. Orchard PJ, Milla C, Braunlin E, DeFor T, Bjoraker K, Blazar BR, Peters C, Wagner J, Tolar J. Pre-transplant risk factors affecting outcome in Hurler syndrome. Bone Marrow Transplant. 2010 Jul;45(7):1239-46. http://dx.doi.org/10.1038/bmt.2009.319. PMID: 19898501.
  122. Zhou Q, Bucher C, Munger ME, Highfill SL, Tolar J, Munn DH, Levine BL, Riddle M, June CH, Vallera DA, Weigel BJ, Blazar BR. Depletion of endogenous tumor-associated regulatory T cells improves the efficacy of adoptive cytotoxic T-cell immunotherapy in murine acute myeloid leukemia. Blood. 2009 Oct 29;114(18):3793-802. http://dx.doi.org/10.1182/blood-2009-03-208181. PMID: 19724059. PMCID: PMC2773484.
  123. Lund TC, Glass TJ, Tolar J, Blazar BR. Expression of telomerase and telomere length are unaffected by either age or limb regeneration in danio rerio. PLoS One. 2009 Nov 6;4(11):e7688. http://dx.doi.org/10.1371/journal.pone.0007688. PMID: 19893630. PMCID: PMC2766636.
  124. Martinez C, Polgreen LE, DeFor TE, Kivisto T, Petryk A, Tolar J*, Orchard PJ* (*co-last authors). Characterization and management of hypercalcemia following transplantation for osteopetrosis. Bone Marrow Transplant. 2010 May;45(5):939-44. http://dx.doi.org/10.1038/bmt.2009.277. PMID: 19802031. 
  125. Blair HC, Yaroslavskiy BB, Robinson LJ, Mapara MY, Pangrazio A, Guo L, Chen K, Vezzoni P, Tolar J, Orchard PJ. Osteopetrosis with micro-lacunar resorption because of defective integrin organization. Lab Invest. 2009 Sep;89(9):1007-17. http://dx.doi.org/10.1038/labinvest.2009.58. PMID: 19546854. PMCID: PMC2856930. 
  126. Highfill SL, Kelly RM, O’Shaughnessy MJ, Zhou Q, Xia L, Panoskaltsis-Mortari A, Taylor PA, Tolar J*, Blazar BR* (*co-last authors). Multipotent adult progenitor cells (MAPC) can suppress graft-versus-host disease via prostaglandin E2 synthesis and only if localized to sites of allopriming. Blood. 2009 Jul 16;114(3):693-701. http://dx.doi.org/10.1182/blood-2009-03-213850. PMID: 19458354. PMCID: PMC2713464.
  127. Tolar J*, Braunlin E*, Riddle M, Peacock B, McElmurry RT, Orchard PJ, Blazar BR. (* co-first authors) Gender-related dimorphism in aortic insufficiency in murine mucopolysaccharidosis Type I. J Heart Valve Dis. 2009 Sep;18(5):524-9. http://www. http://europepmc.org/articles/PMC3541017. PMID: 20099693. PMCID: PMC3541017.
  128. Luscri N, Mauer M, Sarafoglou K, Moran A, Tolar J. Lactic acidosis and hypoglycemia with ALL relapse following hematopoietic cell transplant: a case report and brief review of literature. Pediatr Blood Cancer. 2009 Aug;53(2):223-5. http://dx.doi.org/10.1002/pbc.22010. PMID: 19405138. 
  129. Polgreen LE, Plog M, Schwender JD, Tolar J, Thomas W, Orchard PJ, Miller BS, Petryk A. Short-term growth hormone treatment in children with Hurler syndrome after hematopoietic cell transplantation. Bone Marrow Transplant. 2009 Sep;44(5):279-85. http://dx.doi.org/10.1038/bmt.2009.31. PMID: 19252529. PMCID: PMC3071029. 
  130. Tolar J, Ishida-Yamamoto A, Riddle M, McElmurry RT, Osborn M, Xia L, Lund T, Slattery C, Uitto J, Christiano AM, Wagner JE, Blazar BR. Amelioration of epidermolysis bullosa by transfer of wild-type bone marrow cells. Blood. 2009 Jan 29;113(5):1167-74. [Press release: American Society of Hematology, Dec 3, 2008; Commentary: Inside Blood 2009 Jan 29;113(5):982-3.] http://dx.doi.org/10.1182/blood-2008-06-161299. PMID: 18955559. PMCID: PMC2635082.
  131. Tolar J, Petryk A, Khan K, Bjoraker KJ, Jessurun J, Dolan M, Kivisto T, Charnas L, Shapiro EG, Orchard PJ. Long-term metabolic, endocrine, and neuropsychological outcome of hematopoietic cell transplantation for Wolman disease. Bone Marrow Transplant. 2009 Jan;43(1):21-7. http://dx.doi.org/10.1038/bmt.2008.273. PMID: 18776925.
  132. Osborn MJ, McElmurry RT, Peacock B, Tolar J*, Blazar BR* (*co-last authors). Targeting of the CNS in MPS-IH using a nonviral transferrin-α-L-iduronidase fusion gene product. Mol Ther. 2008 Aug;16(8):1459-66. http://dx.doi.org/10.1038/mt.2008.119. PMID: 18523448. PMCID: PMC2574880.
  133. Harker-Murray PD, Thomas AJ, Wagner JE, Weisdorf D, Luo X, DeFor TE, Verneris MR, Dusenbery KE, MacMillan ML, Tolar J, Baker KS, Orchard PJ. Allogeneic hematopoietic cell transplantation in children with relapsed acute lymphoblastic leukemia isolated to the central nervous system. Biol Blood Marrow Transplant. 2008 Jun;14(6):685-92. http://dx.doi.org/10.1016/j.bbmt.2008.03.011. PMID: 18489994.
  134. Lund TC, Tolar J, Orchard PJ. Granulocyte colony-stimulating factor mobilized CFU-F can be found in the peripheral blood but have limited expansion potential. Haematologica. 2008 Jun;93(6):908-12. http://dx.doi.org/1.3324/haematol.12384. PMID: 18403392. 
  135. Tolar J, Orchard PJ, Key NS, Blazar BR. Circulating anticoagulant glycosaminoglycans in mucopolysaccharidosis type I. J Throm Haemost. 2008 May;6(5):893-5. http://dx.doi.org/10.1111/j.1538-7836.2008.02936. PMID: 18315551. 
  136. Jacobson P, Huang J, Rydholm N, Tran M, DeFor T, Tolar J, Orchard PJ. Higher mycophenolate dose requirements in children undergoing hematopoietic cell transplant (HCT). J Clin Pharmacol. 2008 Apr;48(4):485-94. http://dx.doi.org/10.1177/0091270007313326. PMID: 18296555.
  137. Polgreen LE, Tolar J, Plog M, Himes JH, Orchard PJ, Whitley CB, Miller BS, Petryk A. Growth and endocrine function in patients with Hurler syndrome after hematopoietic stem cell transplantation. Bone Marrow Transplant. 2008 Jun;41(12):1005-11. http://dx.doi.org/10.1038/bmt.2008.20. PMID: 18278070.
  138. Huang X, Guo H, Kang J, Choi S, Zhou TC, Tammana S, Lees CJ, Li ZZ, Milone M, Levine BL, Tolar J, June CH, McIvor RS, Wagner JE, Blazar BR, Zhou X. Sleeping Beauty transposon-mediated engineering of human primary T cells for therapy of CD19+ lymphoid malignancies. Mol Ther. 2008 Mar;16(3):580-9. http://dx.doi.org/10.1038/sj.mt.6300404. PMID: 18227839.
  139. Tolar J, Grewal SS, Bjoraker, KJ, Whitley CB, Shapiro EG, Charnas L, Orchard PJ. Combination of enzyme replacement and hematopoietic stem cell transplantation as therapy for Hurler syndrome. Bone Marrow Transplant. 2008 Mar;41(6):531-5. http://dx.doi.org/10.1038/sj.bmt.1705934. PMID: 18037941. 
  140. Taylor PA, Ehrhardt MJ, Lees CJ, Tolar J, Weigel BJ, Panoskaltsis-Mortari A, Serody JS, Brinkmann V, Blazar BR. Insights into the mechanism of FTY720 and compatibility with regulatory T cells for the inhibition of graft-versus-host disease (GVHD). Blood. 2007 Nov 1;110(9):3480-8. http://dx.doi.org/10.1182/blood-2007-05-087940. PMID: 17606761. PMCID: PMC2200903.
  141. Lee AB, Harker-Murray P, Ferrieri P, Schleiss MR, Tolar J. Bacterial meningitis in patients with malignancy or undergoing hematopoietic stem cell transplantation. Pediatr Blood Cancer. 2008 Mar;50(3):673-6. http://dx.doi.org/10.1002/pbc.21286. PMID: 17588235.
  142. Zayed H, Xia L, Yerich A, Yant SR, Kay MA, Puttaraju M, McGarrity GJ, Wiest DL, McIvor RS, Tolar J*, Blazar BR* (*co-last authors). Correction of DNA protein kinase deficiency by spliceosome-mediated RNA -splicing and transposon delivery. Mol Ther. 2007 Jul;15(7):1273-9. http://dx.doi.org/10.1038/sj.mt.6300178. PMID: 17457319.
  143. Yun G, Tolar J, Yerich AK, Marsh SGE, Robinson J, Noreen H, Blazar BR, Miller JS. A novel method for KIR-ligand typing by pyrosequencing to predict NK cell alloreactivity. Clin Immunol. 2007 Jun;123(3):272-80. http://dx.doi.org/10.1016/j.clim.2007.01.011. PMID: 17446137. PMCID: PMC199128.
  144. Tolar J*, Wang X*, Braunlin E, McElmurry RT, Nakamura Y, Bell S, Xia L, Zhang Jo, Hu Q, Panoskaltsis-Mortari A, Zhang J, Blazar BR (*co-first authors). The host immune response is essential for the beneficial effect of adult stem cells after myocardial ischemia. Exp Hematol. 2007 Apr;35(4):682-90. http://dx.doi.org/10.1016/j.exphem.2006.12.005. Erratum in: Exp Hematol. 2007 Jul;35(7):1153-61. PMID: 17379078.
  145. Tolar J, Orchard PJ, Bjoraker KJ, Ziegler RS, Shapiro EG, Charnas L. N-acetyl-L-cysteine improves outcome of advanced cerebral adrenoleukodystrophy. Bone Marrow Transplant. 2007 Feb;39(4):211-5. http://dx.doi.org/10.1038/sj.bmt.1705571. PMID: 17290278.
  146. Serafini M, Dylla SJ, Oki M, Heremans Y, Tolar J, Jiang Y, Buckley SM, Pelacho B, Burns TC, Frommer S, Rossi DJ, Bryder D, Panoskaltsis-Mortari A, O'Shaughnessy MJ, Nelson-Holte M, Fine GC, Weissman IL, Blazar BR, Verfaillie CM. Hematopoietic reconstitution by multipotent adult progenitor cells: precursors to long-term hematopoietic stem cells. J Exp Med. 2007 Jan 22;204(1):129-39. Erratum in: J Exp Med. 2007 Jul 9;204(7):1729. http://dx.doi.org/10.1084/jem.20061115. PMID: 17227908. PMCID: PMC2118428.
  147. Tolar J, Bonfim C, Grewal S, Orchard P. Engraftment and survival following hematopoietic stem cell transplantation for osteopetrosis using a reduced intensity conditioning regimen. Bone Marrow Transplant. 2006 Dec;38(12):783-7. http://dx.doi.org/10.1038/sj.bmt.1705533. PMID: 17086207.
  148. Tolar J, Nauta AJ, Osborn MJ, Panoskaltsis-Mortari A, McElmurry RT, Bell S, Xia L, Zhou N, Riddle M, Schroeder TM, Westendorf JJ, McIvor RS, Hogendoorn PCW, Szuhai K, Oseth L, Hirsch B, Yant SR, Kay MA, Peister A, Prockop DJ, Fibbe WE, Blazar BR. Sarcoma derived from cultured mesenchymal stem cells. Stem Cells. 2007 Feb;25(2):371-9. Quoted in the Faculty 1000. http://dx.doi.org/10.1634/stemcells.2005-0620. PMID: 17038675.
  149. Brunstein CG, Weisdorf DJ, DeFor T, Barker JN, Tolar J, van Burik JA, Wagner JE. Marked increased risk of Epstein-Barr virus-related complications with the addition of antithymocyte globulin to a nonmyeloablative conditioning prior to unrelated umbilical cord blood transplantation. Blood. 2006 Oct 15;108(8):2874-80. http://dx.doi.org/10.1182/blood-2006-03-011791. PMID: 16804113. PMCID: PMC1895580.
  150. Deeg HJ, O’Donnell M, Tolar J, Agarwal R, Harris RE, Feig SA, Territo MC, Collins RH, McSweeney PA, Copelan EA, Khan SP, Woolfrey A, Storer B. Optimization of conditioning for marrow transplantation from unrelated donors for patients with aplastic anemia after failure of immunosuppressive therapy. Blood. 2006 Sep 1;108(5):1485-91. http://dx.doi.org/10.1182/blood-2006-03-005041. PMID: 16684959. PMCID: PMC1895515.
  151. Subramanian IV, Bui Nguyen TM, Truskinovsky AM, Tolar J, Blazar BR, Ramakrishnan S. Adeno-associated virus-mediated delivery of a mutant endostatin in combination with carboplatin treatment inhibits orthotopic growth of ovarian cancer and improves long-term survival. Cancer Res. 2006 Apr 15;66(8):4319-28. http://dx.doi.org/10.1158/0008-5472.CAN-05-3297. PMID: 16618757.
  152. Tolar J, O’Shaughnessy MJ, Panoskaltsis-Mortari A, McElmurry RT, Bell S, Riddle M, McIvor RS, Yant SR, Kay MA, Krause D, Verfaillie CM, Blazar BR. Host factors that impact the biodistribution and persistence of multipotent adult progenitor cells. Blood. 2006 May 15;107(10):4182-8. http://dx.doi.org/10.1182/blood-2005-08-3289. PMID: 16410448. PMCID: PMC1895284.
  153. Braunlin E, Mackey-Bojack S, Panoskaltsis-Mortari A, Berry JM, McElmurry RT, Riddle M, Sun LY, Clarke LA, Tolar J*, Blazar BR* (*co-last authors). Cardiac functional and histopathologic findings in humans and mice with mucopolysaccharidosis type I: implications for assessment of therapeutic interventions in Hurler syndrome. Pediatr Res. 2006 Jan;59(1):27-32. http://dx.doi.org/10.1203/01.pdr.0000190579.24054.39. PMID: 16326988.
  154. Huang X, Wilber AC, Bao L, Tuong D, Tolar J, Orchard PJ, Levine BL, June CH, McIvor RS, Blazar BR, Zhou X. Stable gene transfer and expression in human primary T cells by the Sleeping Beauty transposon system. Blood. 2006 Jan 15;107(2):483-91. http://dx.doi.org/10.1182/blood-2005-05-2133. PMID: 16189271. PMCID: PMC1895607.
  155. Osborn MJ, Panoskaltsis-Mortari A, McElmurry RT, Bell SK, Vignali DAA, Ryan MD, Wilber AC, McIvor RS, Tolar J, Blazar BR. A picornaviral 2A-like sequence-based tricistronic vector allowing for high-level therapeutic gene expression coupled to a dual-reporter system. Mol Ther. 2005 Sep;12(3):569-74. http://dx.doi.org/10.1016/j.ymthe.2005.04.013. PMID: 15964244.
  156. Tolar J, Osborn M, Bell S, McElmurry R, Xia L, Riddle M, Panoskaltsis-Mortari A, Jiang Y, McIvor RS, Contag CH, Yant SR, Kay MA, Verfaillie CM, Blazar Br. Real-time imaging of stem cells following transgenesis by transposition. Mol Ther. 2005 Jul;12(1):42-8. http://dx.doi.org/10.1016/j.ymthe.2005.02.023. PMID: 15963919.
  157. Tolar J, Bostrom BC, La MK, Sather HN. Intravenous 6-mercaptopurine decreases salvage after relapse in childhood acute lymphoblastic leukemia: a report from the Children’s Cancer Group study CCG 1922. Pediatr Blood Cancer. 2005 Jul;45(1):5-9. http://dx.doi.org/10.1002/pbc.20239. PMID: 15481062.
  158. Wagner JE, Tolar J, Levran O, Scholl T, Deffenbaugh A, Satagopan J, Ben-Porat L, Mah K, Batish SD, Kutler DI, MacMillan ML, Hanenberg H, Auerbach AD. Germline mutations in BRCA2: shared genetic susceptibility to breast cancer, early onset leukemia, and Fanconi anemia. Blood. 2004 Apr 15;103(8):3226-9. http://dx.doi.org/10.1182/blood-2003-09-3138. PMID: 15070707.
  159. Tolar J, Tope WD, Neglia JP. Leukotriene-receptor inhibition for the treatment of systemic mastocytosis. Letter. N Engl J Med. 2004 Feb 12;350(7):735-6. http://dx.doi.org/10.1056/NEJM200402123500723. PMID: 14960756.
  160. Tolar J, Coad JE, Ramsay NKC, Peters C, Davies SM. Lymphoproliferative disorder presenting as pulmonary nodules after bone marrow transplantation. Bone Marrow Transplant. 2001 Oct;28(8):808-10. http://www.nature.com/bmt/journal/v28/n8/full/1703249a.html. PMID: 11781638.
  161. Tolar J, Coad JE, Neglia JP. Transplacental transfer of small-cell carcinoma of the lung. N Engl J Med. 2002 May 9;346(19):1501-2. http://dx.doi.org/10.1056/NEJM200205093461917. PMID: 12000827.
  162. Tolar J, Kravitz G, Walker K, Moertel CL. Acute polyosteal osteomyelitis in a patient with congenital ichthyosis and acute lymphoblastic leukemia. Pediatr Infect Dis J. Brief Report. 2001 Aug;20(8):813-4. http://dx.doi.org/ 10.1097/00006454-200108000-00022. PMID: 11734751.
  163. Ghai J, Ostrow RS, Tolar J, McGlennen RC, Lemke TD, Tobolt D, Liu Z, Faras AJ. The E5 gene product of rhesus papillomavirus is an activator of endogenous Ras and phosphatidylinositol-3′-kinase in NIH 3T3 cells. Proc Natl Acad Sci USA. 1996 Nov 12;93(23):12879-84. http://www.pnas.org/content/93/23/12879.full. PMID: 8917513. PMCID: PMC24014.

Peer-Reviewed Publications – Data Mining

  1. Železný F, Jalovec K, Tolar J. Learning meets sequencing: a generality framework for read-sets. Accepted for the International Conference on Inductive Logic Programming (2014 ILP). http://ida.felk.cvut.cz/zelezny/pubs/ilp.14.pdf. 
  2. Szabóová A, Kuželka O, Železný F, Tolar J. Prediction of DNA-binding proteins from relational features. Proteome Sci 2012;10(1):66. http://dx.doi.org/10.1186/1477-5956-10-66. PMID: 23146001. PMCID: PMC3579737.
  3. Szabóová A, Kuželka O, Železný F, Tolar J. Prediction of DNA-binding propensity of proteins by the ball-histogram method using automatic template search. BMC Bioinformatics 2012 Jun 25;13(Suppl 10):S3. http://dx.doi.org/10.1186/1471-2105-13-S10-S3. PMID: 22759427. PMCID: PMC3382442.
  4. Holec M, Kléma J, Železný F, Tolar J. Comparative evaluation of set-level techniques in predictive classification of gene expression samples. BMC Bioinformatics 2012 Jun 25;13(Suppl 10):S15. http://dx.doi.org/10.1186/1471-2105-13-S10-S15. PMID: 22759420. PMCID: PMC3382436.
  5. Szabóová A, Kuželka O, Morales E, Železný F, Tolar J. Prediction of DNA-binding propensity of proteins by the ball-histogram method. Lect Notes Comput Sc. 2011;6674 LNBI;358-67. http://dx.doi.org/10.1007/978-3-642-21260-4_34.
  6. Kléma J, Holec M, Železný F, Tolar J. Comparative evaluation of set-level techniques in microarray classification. Lect Notes Comput Sc. 2011;6674 LNBI:358-67. http://dx.doi.org/978-3-642-21260-4.
  7. Holec M, Železný F, Kléma J, Tolar J. A comparative evaluation of gene set analysis techniques in predictive classification of expression samples. International Conference on Bioinformatics, Computational Biology, Genomics and Chemoinformatics 2010 (BCBGC 2010). 2010:7-11. https://pdfs.semanticscholar.org/d0cc/b50d27ddd149c3551e149c5a265477845e...
  8. Holec M, Železný F, Kléma J, Tolar J. Integrating multiple-platform expression data through gene set features. Lect Notes Comput Sc. 2009;5542 LNBI:5-17. http://dx.doi.org/10.1007/978-3-642-01551-9_2.
  9. Holec M, Kléma J, Železný F, Bĕnadský J, Tolar J. Cross-genome knowledge-based expression data fusion. International Conference on Bioinformatics, Computational Biology, Genomics and Chemoinformatics 2009 (BCBGC-09). 2009:43-50. http://ida.felk.cvut.cz/klema/publications/BCBGC/bcbgc09.pdf.
  10. Trajkovski I, Lavrač N, Tolar J. SEGS: Search for enriched gene sets in microarray data. J Biomed Inform. 2008 Aug;41(4):588-601. http://dx.doi.org/10.1016/j.jbi.2007.12.001. PMID: 18234563.
  11. Trajkovski I, Lavrač N, Tolar J. Learning relational descriptions of differentially expressed gene groups. IEEE Trans Sys Man Cyb C. 2008;38(1):16-25. http://dx.doi.org/10.1109/TSMCC.2007.906059.
  12. Trajkovski I, Železný F, Tolar J, Lavrač N. Relational subgroup discovery for descriptive analysis of microarray data. Lect Notes Comput Sc. 2006;4216 LNBI:86-96. http://dx.doi.org/ 10.1007/11875741_9.
  13. Trajkovski I, Železný F, Tolar J, Lavrač N. Relational descriptive analysis of gene expression data. Proceedings of STAIRS-2006 (3rd European Starting AI Researcher Symposium) at the 17th European Conference on Artificial Intelligence. Riva del Garda, Italy, 2006. http://ida.felk.cvut.cz/zelezny/pubs/stairs06.pdf. 
  14. Železný F, Tolar J, Lavrač N, Štěpánková O. Summarizing gene-expression-based classifiers by meta-mining comprehensible relational patterns. Proceedings of the Fourth IASTED International Conference on Biomedical Engineering. 2006:19-24. http://citeseerx.ist.psu.edu/viewdoc/download;jsessionid=CE4985CF9B74C1B....
  15. Železný F, Tolar J, Lavrač N, Štěpánková O. Relational subgroup discovery for gene expression data mining. Proceedings of EMBEC'05: the 3rd European Medical & Biological Engineering Conference/IFMBE European Conference on Biomedical Engineering. Prague, Czech Republic, 2005. http://ida.felk.cvut.cz/zelezny/pubs/embec05.pdf. 
  16. Gamberger D, Lavrač N, Železný F, Tolar J. Induction of comprehensible models for gene expression datasets by subgroup discovery methodology. J Biomed Inform. 2004 Aug;37(4):269-84. http://dx.doi.org/10.1016/j.jbi.2004.07.007. PMID: 15465480.

Reviews, Commentaries and Letters to the Editor

  1. Vanden Oever M, Twaroski K, Osborn MJ, Wagner JE, Tolar J. Inside out: regenerative medicine for recessive dystrophic epidermolysis bullosa. Pediatr Res. 2018 Jan;83(1-2):318-324. http://dx.doi.org/10.1038/pr.2017.244. Review. PMID: 29593249. 
  2. Tolar J. Regenerative solutions for inherited diseases. Clin Pharmacol Ther. 2018 May;103(5):763-766. http://dx.doi.org/10.1002/cpt.990. PMID: 29380353.
  3. Yoon DH, Osborn MJ, Tolar J, Kim CJ. Incorporation of immune checkpoint blockade into chimeric antigen receptor T cells (CAR-Ts): Combination or built-in CAR-T. Int J Mol Sci. Review. 2018 Jan 24;19(2). pii: E340. http://dx.doi.org/10.3390/ijms19020340. PMID: 29364163.
  4. Dietz AC, Mehta PA, Vlachos A, Savage SA, Bresters D, Tolar J, Boulad F, Dalle JH, Bonfim C, de la Fuente J, Duncan CN, Baker KS, Pulsipher MA, Lipton JM, Wagner JE, Alter BP. Current knowledge and priorities for future research in late effects after hematopoietic cell transplantation (HCT) for inherited bone marrow failure syndrome (IBMFS): Consensus statement the Second Pediatric Blood and Marrow Transplant Consortium International Conference on Late Effects after Pediatric HCT. Biol Blood Marrow Transplant. Review. 2017 May;23(5):726-735. http://dx.doi.org/10.1016/j.bbmt.2017.01.075. PMID: 28115275. PMCID: PMC5423755.
  5. Navarro S, Giorgetti A, Raya A, Tolar J. Induced pluripotency and gene editing in Fanconi anemia. Curr Gene Ther. Review. 2017 Jan 18;16(5), pp. 321-328. http://dx.doi.org/10.2174/1566523217666170118112050. PMID: 28103772. 
  6. Osborn MJ, Belanto JJ, Tolar J, Voytas DF. Gene editing and its application for hematological diseases. Int J Hematol. Review. 2016 Jul;104(1):18-28. http://dx.doi.org/10.1007%2Fs12185-016-2017-z. PMID: 27233509.
  7. Tolarová M, McGrath JA, Tolar J. Venturing into the new science of nucleases. J Invest Dermatol. Commentary. 2016 Apr;136(4):742-5. http://dx.doi.org/10.1016/j.jid.2016.01.021. PMID: 27012560. PMCID: PMC5320895.
  8. Tolarova M, Tolar J. From mesoderm to mesodermatology: Bone marrow mesenchymal cells heal skin wounds. Mol Ther. Commentary. 2015 Aug;23(8):1283-4. http://dx.doi.org/ 10.1038/mt.2015.84. PMID: 26227251. PMCID: PMC4817871
  9. Perdoni C, Osborn MJ, Tolar J. Gene editing toward the use of autologous therapies in recessive dystrophic epidermolysis bullosa. Transl Res. Review. 2016 Feb;168:50-8. http://dx.doi.org/10.1016/j.trsl.2015.05.008. PMID: 26073463. PMCID: PMC4662628. 
  10. Tolar J. Sickle cell and silent spleen. Blood. Commentary. 2015 April 23;125(17):2589-90. http://dx.doi.org/10.1182/blood-2015-03-633933. PMID: 25907900.
  11. Nevala-Plagemann C, Lee C, Tolar J. Placenta-based therapies for the treatment of epidermolysis bullosa. Cytotherapy. Review. 2015 Jun;17(6):786-95. http://dx.doi.org/10.1016/j.jcyt.2015.03.006. PMID: 25795271. PMCID: PMC4424102.
  12. Webber BR, Tolar J. From marrow to matrix: novel gene and cell therapies for epidermolysis bullosa. Mol Ther. Review. 2015 Jun;23(6):987-92. http://dx.doi.org/10.1038/mt.2015.47. PMID: 25803200. PMCID: PMC4817762.
  13. Tolar J, McGrath JA. The three-body problem of therapy with induced pluripotent stem cells. Genome Med. Research Highlight. 2015 Feb 20;7(1):15. http://dx.doi.org/10.1186/s13073-015-0141-7. PMID: 25705260. PMCID: PMC4335559.
  14. Tolar J, Sodani P, Symons H. Alternative donor transplant of benign primary hematologic disorders. Bone Marrow Transplant. Review. 2015 May;50(5):619-27. http://dx.doi.org/10.1038/bmt.2015.1. PMID: 25665040. PMCID: PMC4424154.
  15. Tolar J, Wagner JE. A biologic Velcro patch. N Engl J Med. Clinical Implications of Basic Research. 2015 Jan 22;372(4):382-4. http://dx.doi.org/10.1056/NEJMcibr1414709. PMID: 25607432.
  16. Tolar J, Tolar M. A living band-aid for epidermolysis bullosa. Blood Transfus. Editorial. 2015 Jan 15;13(1):1-2. http://dx.doi.org/10.2450/2014.0289-14. PMID: 25636127. PMCID: PMC4317083.
  17. Tolar J, McGrath JA. Augmentation of cutaneous wound healing by pharmacologic mobilization of endogenous bone marrow stem cells. J Invest Dermatol. Commentary. 2014 Sep;134(9):2312-4. http://dx.doi.org/10.1038/jid.2014.209. PMID: 25120149.
  18. Tolar J, Tolarova S, McGrath JA. On Medawar’s ‘Actively acquired tolerance of foreign cells’. Exp Dermatol. Commentary: My Favorite Historical Paper. 2014 Feb;23(2):97-8. http://dx.doi.org/10.1111/exd.12227. PMID: 24476006. 
  19. Vanden Oever MJ, Tolar J. Advances in understanding and treating dystrophic epidermolysis bullosa. F1000Prime Rep. 2014 May 6;6:35. http://dx.doi.org/10.12703/p6-35. PMID: 24860657. PMCID: PMC4017907.
  20. Tolar J. Translating genome engineering to better clinical outcomes. Transl Res. Commentary. 2013 Apr;161(4):199-204. http://dx.doi.org/10.1016/j.trsl.2013.01.004. PMID: 23416084. 
  21. Tolar J, Tolar M. Reinventing mesenchymal stromal cells. Cytotherapy. Commentary. 2012 Apr;14(4):388-90. http://dx.doi.org/10.3109/14653249.2012.665631. PMID: 22420833.
  22. Tolar J, Wagner JE. Management of severe epidermolysis bullosa by hematopoietic transplant: Principles, perspectives, and pitfalls. Exper Dermatol. Viewpoints. 2012 Dec;21(12):896-900. http://dx.doi.org/10.1111/exd.12014. PMID: 23016552.
  23. Tolar J, Becker PS, Clapp DW, Hanenberg H, de Heredia CD, Kiem HP, Navarro S, Qasba P, Rio P, Schmidt M, Sevilla J, Verhoeyen E, Thrasher AJ, Bueren J. Gene therapy for Fanconi anemia: one step closer to the clinic. Hum Gene Ther. Commentary. 2012 Feb;23(2):141-4. http://dx.doi.org/10.1089/hum.2011.237. PMID: 22248350. PMCID: PMC3277737.
  24. Tolar J, Mehta PA, Walters MC. Hematopoietic cell transplantation for nonmalignant disorders. Biol Blood Marrow Transplant. Review. 2012 Jan;18(1 Suppl):S166-71. http://dx.doi.org/10.1016/j.bbmt.2011.10.023. PMID: 22226101.
  25. Tolar J, Blazar BR, Wagner JE. Concise review: Transplantation of human hematopoietic cells for extracellular matrix protein deficiency in epidermolysis bullosa. Stem Cells. 2011;29(6):900-6. Cited in Cord Blood News 2011;(20) 26 May 2011. Cited in Global Medical Discovery (website). http://dx.doi.org/10.1002/stem.647. PMID: 21557391.
  26. Tolar J, Adair JE, Antoniou M, Bartholomae CC, Becker PS, Blazar BR, Bueren J, Carroll T, Cavazzana-Calvo M, Clapp DW, Dalgleish R, Galy A, Gaspar HB, Hanenberg H, Von Kalle C, Kiem HP, Lindeman D, Naldini L, Navarro S, Renella R, Rio P, Sevilla J, Schmidt M, Verhoeyen E, Wagner JE, Williams DA, Thrasher AJ. stem cell gene therapy for Fanconi anemia: Report from the 1st International Fanconi Anemia Gene Therapy Working Group Meeting. Mol Ther. Review. 2011 Jul;19(7):1193-8. http://dx.doi.org/10.1038/mt.2011.78. PMID: 21540837. PMCID: PMC3129570.
  27. Tolar J, Villeneuve P, Keating A. Mesenchymal stromal cells for graft-versus-host disease. Hum Gene Ther. Review. 2011;22(3):257-62. http://dx.doi.org/10.1089/hum.2011.1104. PMID: 21288086.
  28. Tolar J, Le Blanc K, Keating A, Blazar BR. Concise review: hitting the right spot with mesenchymal cells. Stem Cells. 2010 Aug;28(8):1446-55. http://dx.doi.org/10.1002/stem.459. PMID: 20597105. PMCID: PMC3638893.
  29. Boelens JJ*, Prasad VK*, Tolar J*, Wynn RF*, Peters C (*co-first authors). Current international perspectives on hematopoietic stem cell transplantation for inherited metabolic disorders. Pediatr Clin North Am. Review. 2010 Feb;57(1):123-45. http://dx.doi.org/10.1016/j.pcl.2009.11.004. PMID: 20307715.
  30. Tolar J, Baker KS, Orchard P. Hematopoietic stem cell transplantation for metabolic storage diseases. Cell Ther Transplant. Review. 2010;2(7):e.000075.01. http://www.ctt-journal.com/2-7-en-tolar-et-al-2010mar22.html.
  31. Tolar J, Eapen M, Orchard PJ, Blazar BR. Acid sphingomyelinase deficiency does not protect from graft-versus-host disease in transplant recipients with Niemann-Pick disease. Blood. Letter to the Editor. 2010 Jan 14;115(2):434-5. http://dx.doi.org/10.1182/blood-2009-09-245167. PMID: 20075175.
  32. Tolar J, Hippen KL, Blazar BR. Immune regulatory cells in umbilical cord blood: T regulatory cells and mesenchymal stromal cells. Brit J Haematol. Review. 2009;147(2):200-6. http://dx.doi.org/10.1111/j.1365-2141.2009.07781.x. PMID: 19796269. PMCID: PMC3667699.
  33. Savage SA, Dokal I, Armanios M, Aubert G, Cowen EW, Domingo DL, Giri N, Greene MH, Orchard PJ, Tolar J, Tsilou E, Van Waes C, Wong JMY, Young NS, Alter BP. Dyskeratosis congenita: the first NIH Clinical Research Workshop. Pediatr Blood Cancer. Meeting Report. 2009 Sep;53(3):520-3. http://dx.doi.org/10.1002/pbc.22061. PMID: 19415736. PMCID: PMC2739803.
  34. Tolar J, Neglia JP. Reply to: Case 4-2008: A pregnant woman with a swollen left breast and dyspnea. N Engl J Med. 2008 Jun 26;358(26):2848; author reply 2848-9. http://dx.doi.org/10.1056/nejmc080467. PMID: 18579826.
  35. Lund T, Tolar J. Reply to: Chimerism and tolerance in a recipient of a deceased-donor liver transplant. N Engl J Med. 2008 May 8;358(19):2075; author reply 2075. http://dx.doi.org/10.1056/nejmc080395. PMID: 18463388.
  36. Charnas L, Eichler F, Kohlschuetter A, Tolar J, Orchard PJ. Reply to: Reduced intensity conditioning haematopoietic stem cell transplantation with mesenchymal stromal cell infusion for the treatment of metachromatic leukodystrophy: a case report. Haematologica. 2008 May;93(5):e47; author reply e48. http://dx.doi.org/10.3324/haematol.12774. PMID: 18450730.
  37. Krishnamurti L, Bunn HF, Williams AM, Tolar J. Hematopoietic cell transplantation for hemoglobinopathies. Curr Prob Pediatr Adolesc Health Care. Review. 2008 Jan;38(1):6-18. http://dx.doi.org/10.1016/j.cppeds.2007.10.002. PMID: 18068866.
  38. Orchard PJ, Blazar BR, Wagner J, Charnas L, Krivit W, Tolar J. Hematopoietic cell therapy for metabolic disease. J Pediatr. Medical Progress. 2007 Oct;151(4):340-6. http://dx.doi.org/10.1016/j.jpeds.2007.04.054. PMID: 17889065.
  39. Tolar J, Orchard, P. Alpha-L-iduronidase therapy for mucopolysaccharidosis type I. Biologics. Review. 2008;2(4):743-51. Views as of 4/28/2016: 8,856. http://dx.doi.org/10.2147/BTT.S3180. PMID: 19707455. PMCID: PMC2727896.
  40. Tolar J, Teitelbaum SL, Orchard PJ. Osteopetrosis. N Engl J Med. Review. Mechanisms of disease. 2004 Dec 30;351(27):2839-49. http://dx.doi.org/10.1056/NEJMra040952. PMID: 15625335.
  41. Tolar J, Baker KS. New approaches in pediatric hematopoietic stem cell transplantation. Ebonyi Medical Journal 2:7-12, 2003.
  42. Tolar J, Neglia JP. Transplacental and other routes of cancer transmission between individuals. J Pediatr Hematol Oncol. Review. 2003 Jun;25(6):430-4. http://journals.lww.com/jpho-online/Abstract/2003/06000/Transplacental_a.... PMID: 12794519.

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