Moriarity Laboratory

Moriarity Lab

Moriarity Lab Contact Info

Lab Address
Cancer & Cardiovascular Research Building
2231 6th St SE, RM 2-230
Minneapolis, MN 55455

Lab Phone 

Mailing Address
Masonic Cancer Research Ctr
1st Floor Mailroom CCRB
2231 6th St SE
Minneapolis, MN 55455

Administrative Assistant
Rebecca Ingison

Administrative Email

Research Interests

  • Pediatric cancer genetics
  • Gene and immunotherapy
  • Genome engineering

Dr. Moriarity's laboratory is working on studying the genetics of pediatric cancer, including sarcomas and brain tumors, to identify novel therapeutic targets to better treat pediatric cancer patients. The Moriarity lab uses animal models and comparative genomics approaches to identify new candidate cancer genes. Once identified, candidate genes are functionally studied in human cancer and immortalized cell lines using cutting edge technologies, such as targeted nucleases. The primary targeted nucleases used in the Moriarity lab are the CRISPR/Cas9 and Transcriptional Activator-Like Effector (TALEN) systems, which are used to knockout genes, induce targeted sequence changes, activate and/or repress endogenous gene expression. 

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