Largaespada Lab

Largaespada Lab

Largaespada Lab Contact Info

Lab Address (visit us):
Cancer & Cardiovascular Research Building
2231 6th St SE, RM 3-230
Minneapolis, MN 55455

Lab Phone: 612-626-6971

Mailing Address:
Masonic Cancer Research Ctr
1st Floor Mailroom CCRB
2231 6th St SE
Minneapolis, MN 55455

Administrative Assistant Name
Rebecca Ingison

Administrative Phone

Administrative Email

Working to exploit insertional mutagenesis for cancer gene discovery since 1996. 

Research projects in the Largaespada lab are aimed at identifying mutations and other changes that drive the development of cancer, which must be determined for developing molecularly targeted therapeutics.

Sleeping Beauty

The Largaespada lab pioneered the use of a vertebrate-active transposon system, called Sleeping Beauty (SB), for insertional mutagenesis in mouse somatic cells. SB is being used as a tool for forward genetic screens for cancer genes involved in sarcoma, hepatocellular carcinoma, mammary, gastro-intestinal tract and NF1 syndrome-associated nervous system cancers.

Sleeping Beauty Illustration













Novel Mouse Models


Also, novel mouse models are being used for preclinical evaluation of new drugs and drug combinations for cancer treatment. A large focus is on drugs to treat tumors associated with Neurofibromatosis Type 1 (NF1) syndrome.

Molecular Biology

The lab is also working to utilize and improve the latest methods in genome engineering, like CRISPR/Cas9, to study cancer gene function and uncover cancer vulnerabilities.