Many Department of Pediatrics faculty members have their own laboratories, where they work to generate new knowledge through research.
Faculty pursue a wide range of research interests, such as childhood cancer, stem cell therapies, global health, transplantation, type 1 diabetes, kidney disease, newborn care, and childhood health conditions that lead to chronic diseases in adults.
To explore their research interests, visit our faculty bio pages or the individual labs below.
Immunobiology and transplantation are the main research interest in the Blazar Laboratory. Project areas include:
- Graft-versus-host disease
- Regulatory T Cells
- Immune recovery and regeneration post-transplant
- Genetic manipulations and reprogramming of immature and mature cells
The Largaespada lab works to exploit mutagenesis for cancer gene discovery. Some key methods used include:
- Sleeping Beauty
- New Mouse Models
- Molecular Biology
- Neurofibromatosis Type 1
- Brain Tumors
Dr. Moriarity’s laboratory is working on studying the genetics of pediatric cancer, including sarcomas and brain tumors, to identify novel therapeutic targets to better treat pediatric cancer patients.
- Genome Engineering
- Gene Therapy
- Cancer Immunotherapy
- Pediatric Cancer Genetics
- Technology Development
The Tolar Laboratory focuses on finding new ways of treating children with lethal diseases. Additional research areas include:
- Reducing the negative effects of stem cell transplantation
- Creation and use of induced pluripotent stem cells
- Gene therapy using gene addition
- Gene editing
The Tran Lab investigates the effects of early-life iron deficiency on the regulation of neural gene expression. Additional research interest include:
- Learning and memory
- Neonatal ischemic stroke
- Molecular biology of nicotinic acetylcholine receptor regulator