Research Laboratories and Programs

Many Department of Pediatrics faculty members have their own laboratories, where they work to generate new knowledge through research.

Faculty pursue a wide range of research interests, such as childhood cancer, stem cell therapies, global health, transplantation, type 1 diabetes, kidney disease, newborn care, and childhood health conditions that lead to chronic diseases in adults.

To explore their research interests, visit our faculty bio pages or the individual labs below. 

Blazar Laboratory

Blazar Laboratory

Blazar Lab

Immunobiology and transplantation are the main research interest in the Blazar Laboratory. Project areas include:

  • Graft-versus-host disease
  • Regulatory T Cells
  • Immune recovery and regeneration post-transplant
  • Graft-versus-leukemia
  • Genetic manipulations and reprogramming of immature and mature cells

Learn more about the Blazar Laboratory

Cusick Lab for Global Nutrition Research

Cusick Lab for Global Nutrition Research

Dr. Cusick’s research aims to elucidate micronutrient and infectious disease interactions, with an ultimate goal of optimizing the health and neurobehavioral development of children living in resource-poor settings.

Learn more about the Cusick Lab for Global Nutrition Research

Largaespada Laboratory

Largaespada Laboratory

The Largaespada lab works to exploit mutagenesis for cancer gene discovery. Some key methods used include:

  • Sleeping Beauty
  • New Mouse Models
  • Molecular Biology
  • Neurofibromatosis Type 1
  • Sarcoma
  • Brain Tumors

Learn more about the Largaespada Laboratory

Moriarity Laboratory

Moriarity Laboratory

Dr. Moriarity’s laboratory is working on studying the genetics of pediatric cancer, including sarcomas and brain tumors, to identify novel therapeutic targets to better treat pediatric cancer patients.

  • Genome Engineering
  • Gene Therapy
  • Cancer Immunotherapy
  • Pediatric Cancer Genetics
  • Technology Development

Learn more about the Moriarity Laboratory

Panoskaltsis - Mortari Laboratory

Panoskaltsis - Mortari Laboratory

The Panoskaltsis-Mortari laboratory is centered on the field of regenerative medicine. We study tissue engineering from stem cells using two approaches:

  1. Decellularized whole organ scaffolds integrated with sophisticated bioreactors
  2. 3D Bioprinting using extrusion, suspension, and laser-assisted techniques

Learn more about the Panoskaltsis-Mortari Laboratory 

 

Tolar Laboratory

Tolar Laboratory

The Tolar Laboratory focuses on finding new ways of treating children with lethal diseases. Additional research areas include: 

  • Reducing the negative effects of stem cell transplantation
  • Creation and use of induced pluripotent stem cells
  • Gene therapy using gene addition 
  • Gene editing 

Learn more about the Tolar Laboratory

Pediatric Developmental Neurobehavioral Science Research Group

Georgieff Laboratory in Developmental Nutritional Neuroscience

Georgieff Laboratory in Developmental Nutritional Neuroscience

The Georgieff Laboratory In Developmental Neutritional Neuroscience focuses on neonatal iron nutrition & metabolism and the developing brain, and specifically the hippocampus, which underlies recognition memory processing. We now understand through the work of our laboratory that adult mental health has its beginnings in the perinatal period and that failure to provide the optimal environment in that period can have life-long consequences. Thus, the real cost to society of early life adversity, including nutrient deficits, is the lost educational and job potential because of failure to “construct” the brain during its critical periods of development. 

Learn more about the Georgieff Laboratory in Development Nutritional Neuroscience

Tran Laboratory

Tran Laboratory

The Tran Lab investigates the effects of early-life iron deficiency on the regulation of neural gene expression. Additional research interest include:

  • Learning and memory
  • Neonatal ischemic stroke
  • Molecular biology of nicotinic acetylcholine receptor regulator

Learn more about the Tran Laboratory

Want your lab added?

Email Emily Kukacka at kukac003@umn.edu to get more information on how to get your research lab or program showcased.