Mark R. Schleiss, MD

Professor, Department of Pediatrics

Mark R. Schleiss

Contact Info

Office Phone 612-626-9913

Fax 612-624-8927

Office Address:
Pediatric Infectious Diseases
Room 3-214 MTRF
2001 6th Street SE
Minneapolis, MN 55455

Mailing Address:
Pediatric Infectious Diseases
2001 6th St SE
Minneapolis, MN 55455

MD, Oregon Health Services University School of Medicine, Portland, OR

Residency in Pediatrics, Oregon Health Sciences University, Portland, OR

Fellowship in Pediatric Infectious Diseases, Children's Hospital Medical Center - University of Washington, Seattle, WA

Fellowship in Molecular Medicine, Fred Hutchinson Cancer Research Center, Seattle, WA


Mark R. Schleiss, MD is a Professor of Pediatrics in the University of Minnesota Medical School. Dr. Schleiss received his MD degree from the Oregon Health and Sciences University, Portland, Oregon. He completed his residency at Doernbecher Children’s Hospital, Oregon Health and Sciences University, Portland, Oregon and his Pediatric Infectious Diseases fellowship at Children’s Hospital Medical Center, University of Washington, Seattle, Washington. He also completed a fellowship in Molecular Medicine studying cytomegalovirus molecular genetics at the Fred Hutchinson Cancer Research Center, Seattle, Washington. 

His laboratory at the UMN Center for Infectious Diseases and Microbiology Translational Research is described at this link:

Dr. Schleiss is also a part of the program "If You Don't Pass, Screen," which aims to increase knowledge and awareness about the problem of congenital cytomegalovirus (CMV) infection in Minnesota. Read more about the program here:



Awards & Recognition

  • Member, Immunity and Host Defense (IHD) Study Section, National Institutes of Health, (2009-present)
  • Board Member, Brendan M. McGinnis Congenital CMV Foundation (2009-present)
  • Minneapolis - St. Paul “Top Doctors” (2013-2018)
  • Minnesota Monthly "Top Doctors" (2018) 
  • Innovator in Translational Research, Department of Pediatrics, University of Minnesota (2017)
  • Voted one of 99 physicians to Best Doctors; University of Minnesota Amplatz Children’s Hospital, Pediatric Infectious Diseases (2009-2013)
  • Society for Pediatric Research, Secretary - Treasurer (2005-2009)
  • Member of Federation of Pediatric Organizations (FOPO) and Pediatric Education Steering Committee (2001-2009)
  • Clinical Infectious Diseases (CID) Award, for Outstanding Review (2006)
  • Golden Spoon House Staff Teaching Award, Cincinnati Children’s Hospital (2003-2004)
  • Council Member, Society for Pediatric Research (2000-2003)
  • American Academy of Pediatrics, Editorial Board, Healthy Kids Magazine (2000-2002)
  • Mead-Johnson Teaching Award, Children’s Hospital Medical Center, Cincinnati, Ohio (1999, 2001)
  • Distinguished Service Award, The Arc, Hamilton County, Ohio (1995)


Research Summary/Interests

Congenital infection with CMV is a major public health problem in the United States today, and is responsible for substantial morbidity in newborns. Dr. Schleiss is engaged in the study of CMV vaccines, immunopathogenesis, and placental infection. Using a variety of vaccine strategies, including purified protein subunit and DNA vaccines, his lab is evaluating the extent of protection of the maternal-placental-fetal unit against CMV infection and disease, using animal models of infection. These studies integrate molecular virology with immunological endpoints to understand in greater detail the aspects of the maternal immune response that are critical in protection of the fetus. Translational research is examining the feasibility of establishing newborn screening programs for congenital CMV infection.




  • Epidemiology


Pediatric Specialty Care-Discovery Clinic

Board Certifications

  • American Board of Pediatrics
  • American Board of Pediatrics - Pediatric Infectious Diseases

Clinical Interests