Janet Hume, MD, PhD

Assistant Professor, Department of Pediatrics

Janet Hume

Contact Info

jrhume@umn.edu

Office Phone 612-624-9574

Office Address:
Pediatric Critical Care Medicine
MB530
5th Floor East Building
2450 Riverside Ave
Minneapolis, MN 55454

Mailing Address:
Pediatric Critical Care Medicine
5th Floor East Building
8951G (Campus Delivery Code)
2450 Riverside Ave
Minneapolis, MN 55454

MD, University of Iowa Carver College of Medicine, Iowa City, IA

Residency in Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR

Fellowship in Pediatric Critical Care, University of Texas Southwestern Medical Center, Dallas, TX

PhD, Microbiology, University of Iowa Carver College of Medicine, Iowa City, IA

Summary

Dr. Hume is an Assistant Professor of Pediatrics in the Division of Pediatric Critical Care. She received her MD and PhD (Microbiology) at the University of Iowa Carver College of Medicine. She then underwent residency training in pediatrics at the University of Arkansas for Medical Sciences, and fellowship training in pediatric critical care at the University of Texas Southwestern Medical Center.

Her research and clinical interests include sepsis and other pathophysiologic processes involving a dysregulated inflammatory/immune response. Dr. Hume’s research projects have included studying myocardial dysfunction in community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) sepsis in a mouse model. She has also been involved as local PI in several multicenter studies through the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) network. These studies include Sepsis Prevalence, Outcomes and Therapies (SPROUT); Pathogen Identification in Pediatric Hematopoietic Stem Cell Transplant Patients with Suspected Lower Respiratory Tract Infection; Pediatric Acute Respiratory Distress Syndrome Incidence and Epidemiology (PARDIE); and Sepsis-induced Red Cell Dysfunction (SiRD).

Dr. Hume is part of the team running the Special Pathogens Unit (SPU) at the University of Minnesota Medical Center, one of 10 Regional Ebola and Special Pathogens Treatment Centers in the US. These centers were established as part of the response to the West African Ebola epidemic as a resource for treating patients with Ebola virus and other high consequence infectious diseases. She has also been involved with the development of the Special Pathogens Research Network, which is intended to facilitate clinical and basic research on high consequence infectious diseases among the 10 regional treatment centers.

Awards & Recognition

  • Minneapolis - St. Paul “Top Doctors, Rising Star Edition” (2019)
  • Donald E. Hill, M.D. Memorial Award for excellence in research (2008)
  • UAMS Chairman’s Scholars Program in Pediatrics (2005-2008)
  • Iowa City Free Medical Clinic Scholarship (2001)

Research

Research Summary/Interests

Sepsis; systemic inflammatory response syndrome (SIRS); inflammatory response; acute respiratory distress syndrome (ARDS)/acute lung injury (ALI); MRSA infection, pathophysiology, and epidemiology; high consequence infectious diseases (particularly impact on pediatric populations).

Publications

  1. Heith CS, Hume JR, Steiner ME, Fischer GA; Fulminant Mycoplasma Infection Requiring ECMO in a Previously Healthy Child: Case Report and Review. Journal of Pediatric Intensive Care. In press 2017.
  2. Lindell RB, Gertz SJ, Rowan CM, McArthur J, Beske F, Plunkett A, Weiss SL, Thomas NJ, Nadkarni VM, Fitzgerald JC; Sepsis Prevalence, Outcomes, Therapies and Study Investigators and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network.High Levels of Morbidity and Mortality Among Pediatric Hematopoietic Cell Transplant Recipients With Severe Sepsis: Insights From the Sepsis Prevalence, Outcomes, and Therapies International Point Prevalence Study.Pediatric Crit Care Med. 2017 E-published ahead of print.
  3. Lin JC, Spinella PC, Fitzgerald JC, Tucci M, Bush JL, Nadkarni VM, Thomas NJ, Weiss SL; Sepsis Prevalence, Outcomes, and Therapy Study Investigators. New or Progressive Multiple Organ Dysfunction Syndrome in Pediatric Severe Sepsis: A Sepsis Phenotype With Higher Morbidity and Mortality. Pediatric Crit Care Med. 2017 Jan;18(1):8-16.
  4. Giuliano JS Jr, Markovitz BP, Brierley J, Levin R, Williams G, Lum LC, Dorofaeff T, Cruces P, Bush JL, Keele L, Nadkarni VM, Thomas NJ, Fitzgerald JC, Weiss SL; Sepsis PRevalence, OUtcomes, and Therapies Study Investigators and Pediatric Acute Lung Injury and Sepsis Investigators Network. Comparison of Pediatric Severe Sepsis Managed in U.S. and European ICUs. Pediatr Crit Care Med. 2016 Jun;17(6):522-30.
  5. Fitzgerald JC, Basu RK, Akcan-Arikan A, Izquierdo LM, Piñeres Olave BE, Hassinger AB, Szczepanska M, Deep A, Williams D, Sapru A, Roy JA, Nadkarni VM, Thomas NJ, Weiss SL, Furth S; Sepsis PRevalence, OUtcomes, and Therapies Study Investigators and Pediatric Acute Lung Injury and Sepsis Investigators Network. Acute Kidney Injury in Pediatric Severe Sepsis: An Independent Risk Factor for Death and New Disability. Crit Care Med. 2016 Dec;44(12):2241-2250.
  6. Weiss SL, Fitzgerald JC, Maffei FA, Kane JM, Rodriguez-Nunez A, Hsing DD, Franzon D, Kee SY, Bush JL, Roy JA, Thomas NJ, Nadkarni VM; SPROUT Study Investigators and Pediatric Acute Lung Injury and Sepsis Investigators Network. Discordant identification of pediatric severe sepsis by research and clinical definitions in the SPROUT international point prevalence study. Crit Care. 2015 Sep 16;19:325
  7. Weiss SL, Fitzgerald JC, Pappachan J, Wheeler D, Jaramillo-Bustamante JC, Salloo A, Singhi SC, Erickson S, Roy JA, Bush JL, Nadkarni VM, Thomas NJ; Sepsis Prevalence, Outcomes, and Therapies (SPROUT) Study Investigators and Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Global epidemiology of pediatric severe sepsis: the sepsis prevalence, outcomes, and therapies study. Am J Respir Crit Care Med. 2015 May 15;191(10):1147-57
  8. Janet R. Hume, Sameer Gupta, and Marie E. Steiner. Historical Outcomes of Pediatric HSCT Patients Requiring Critical Care. Journal of Pediatric Intensive Care. 2014; 3;83–90
  9. Hendrik Schultz, Janet Hume, DeSheng Zhang, Miranda Curtiss, Jerrold P. Weiss. A novel role for the bactericidal/permeability-increasing protein (BPI) in interactions of Gram-negative bacterial outer membrane blebs with dendritic cells. J Immunol2007;179: 2477-84. http://www.jimmunol.org/content/179/4/2477 Impact factor: 4.922 (2014), 25 citations as of 1/29/2016 Contribution: Conducted experimental studies

Clinical

Board Certifications

  • American Board of Pediatrics
  • American Board of Pediatrics - Pediatric Critical Care Medicine 

Clinical Interests

Sepsis epidemiology, recognition, treatment and outcomes; acute respiratory distress syndrome (ARDS)/acute lung injury (ALI) epidemiology, treatment and outcomes; improving treatment and outcomes for hematopoietic stem cell transplant (HSCT) patients in PICU; epidemiology, treatment and outcomes of pediatric patients with high consequence infectious diseases.